Delta-aminolevulinate dehydratase activity and oxidative profile in pregnant women with pre-gestational type 2 diabetes and gestational diabetes
DOI:
https://doi.org/10.31686/ijier.vol8.iss1.2154Keywords:
biomarkers, δ-ALA-D, diabetes mellitus in pregnancy, oxidative markers, pregnant womenAbstract
The aim of this study was to perform a comparative evaluation between pregnant women: healthy, with pre-gestational type 2 diabetes (T2DM) and gestational diabetes mellitus (GDM), to determine if diabetes mellitus developed at different times interferes with the oxidative impact on the pregnant woman maternal body. A total of 90 pregnant women were recruited in the third trimester of pregnancy, subdivided into the three groups, and evaluated through their clinical characteristics, oxidative stress markers and delta-aminolevulinate dehydratase (δ-ALA- D) activity. Pregnant women with diabetes mellitus (DM) showed an increase in: age, pre-gestational and gestational body mass index (BMI), blood pressure, blood glucose and platelet count; those with T2DM had higher pre-gestational BMI and glycated hemoglobin A1c (HbA1c). The levels of thiobarbituric acid reactive substances were higher and the levels of non-protein thiols and catalase activity were lower in the DM groups compared to the control. Vitamin C was decreased in the T2DM group. The δ-ALA-D activity was decreased in pregnant women with GDM and the rate of enzymatic reactivation was higher in the DM groups. DM presented in gestation, regardless of the moment of its development, generates increase of the oxidative stress and decrease of the antioxidant defences, representing the largest difference with the control group. It is suggested that the insulin used in the treatment of T2DM acts in a beneficial way in the δ-ALA-D activity.
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References
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Boyne, A. F., Ellman, G. L. 1972. A methodology for analysis of tissue sulfhydryl components. Analytical Biochemistry, 46(2):639–653.
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Cuffe, J. S. M., Xu, Z. C., Perkins, A. V. 2017. Biomarkers of oxidative stress in pregnancy complications. Biomarkers in Medicine, 11(3):295-306.
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Lapenna, D., Ciofani, G., Pierdomenico, S. D., Giamberardino, M. A., Cuccurullo, F. 2001. Reaction conditions affecting the relationship between thiobarbituric acid reactivity and lipid peroxides in human plasma. Free Radical Biology & Medicine, 31(3):331–5.
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Murthy, K. A. S., Bhandiwada, A., Chandan, S. L., Gowda, S. L., Sindhusree, G. 2018. Evaluation of oxidative stress and proinflamatory cytokines in gestational diabetes mellitus and their correlation with pregnancy outcome. Indian Journal of Endocrinology and Metabolism, 22(1):79-84.
Palma, H. E., Wolkmer, P., Gallio, M., Corrêa, M. M., Schmatz, R., Thomé, G. R., Pereira, L. B., Castro, V. S., Pereira, A. B., Bueno, A., de Oliveira, L. S., Rosolen, D., Mann, T. R., de Cecco, B. S., Graça, D. L., Lopes, S. T. A., Mazzanti, C. M. A. 2014. Oxidative stress parameters in blood, liver, and kidney of diabetic rats treated with curcumin and/or insulin. Molecular and Cellular Biochemistry, 386(1-2):199-210.
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Rueangdetnarong, H., Sekararithi, R., Jaiwongkam, T., Kumfu, S., Chattipakorn, N., Tongsong, T., Jatavan, P. 2018. Comparisons of the oxidative stress biomarkers levels in gestational diabetes mellitus (GDM) and non-GDM among Thai-population: cohort study. Endocrine Connection, 7(5):681-7.
Sahbaz, A., Cicekler, H., Aynioglu, O., Isik, H., Ozmen, U. 2016. Comparison of the predictive value of plateletcrit with various other blood parameters in gestational diabetes development. Journal of Obstetrics Gynaecology, 36(5):589-93.
Sato, T., Sugiyama, T., Kurakata, M., Saito, M., Sugawara, J., Yaegashi, N., Sagawa, N., Sanaka, M., Akazawa, S., Anazawa, S., Waguri, M., Sameshima, H., Hiramatsu, Y., Toyoda, N. 2014. Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study Japan. Endocrine Journal, 61(8):759-764.
Shang, M., Zhao, J., Yang, L., Lin, L. 2015. Oxidative stress and antioxidant status in women with gestational diabetes mellitus diagnosed by IADPSG criteria. Diabetes Research and Clinical Practice, 109(2):404-10.
Sociedade Brasileira de Diabetes. 2017. Guidelines of the Brazilian Diabetes Society 2017-2018. São Paulo: Clannad, 383 p.
Souza, J. B., Rocha, J. B. T., Nogueira, C. W., Borges, V. C., Kaizer, R. R., Morsch, V. M., Dressler, V. L., Martins, A. F., Flores, E. M. M., Schetinger, M. R. C. 2007. Delta-aminolevulinate dehydratase (δ-ALA-D) activity in diabetes and hypothyroidism. Clinical Biochemistry, 40(5-6):321-5.
Sugiyama, T., Saito, M., Nishigori, H., Nagase, S., Yaegashi, N., Sagawa, N., Kawano, R., Ichihara, K., Sanaka, M., Akazawa, S., Anazawa, S., Waguri, M., Sameshima, H., Hiramatsu, Y., Toyoda, N. 2014. Comparison of pregnancy outcomes between women with gestational diabetes and overt diabetes first diagnosed in pregnancy: a retrospective multi-institutional study in Japan. Diabetes Research and Clinical Practice, 103(1):20-5.
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Witczak, M., Wilczyńskic, J., Gulczyńskab, E., Talarb, T., Mordalskaa, A., Łopaczyńskaa, D., Ferenca, T. 2017.What is the impact of gestational diabetes mellitus on frequency of structural chromosome aberrations in pregnant women and their offspring? Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 818:27-30.
Zanini, D., Pelinson, L. P., Schmatz, R., Pereira, L. B., Martins, C. C., Baldissareli, J., Amaral, G. P., Soares, F. A. A., Reetz, L. G. B, Araújo, M. C., Chiesa, J., Morsch, V. M., Leal, D. B. R., Schetinger, M. R. 2014. δ-aminolevulinate dehydratase activity in lung cancer patients and its relationship with oxidative stress. Biomedicine & Pharmacotherapy, 68(5):603-9.
Alberico, S., Montico, M., Barresi, V., Monasta, L., Businelli, C., Soini, V., Erenbourg, A., Ronfani, L., Maso, G. 2014. The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy and Childbirth, 14:23.
Araújo, J. R., Keating, E., Martel, F. 2015. Impact of gestational diabetes mellitus in the maternal-to-fetal transport of nutrients. Current Diabetes Report, 15(1).
Arribas, L., Almansa, I., Miranda, M., Muriach, M., Romero, F. J., Villar, V. M. 2016. Serum malondialdehyde concentration and glutathione peroxidase activity in a longitudinal study of gestational diabetes. PLoS One, 11(5): e0155353.
Berlin, A., Schaller, K. H. 1974. European standardized method for the determination of δ- aminolevulinic acid dehydratase activity in blood. Zeitschrift für Klinische Chemie und Klinische Biochemie, 12(8):389–90.
Bonfanti, G., Ceolin, R. B., Valcorte, T., Bona, K. S., Lucca, L., Gonçalves, T. L., Moretto, M. B. 2011. δ-Aminolevulinate dehydratase activity in type 2 diabetic patients and its association with lipid profile and oxidative stress. Clinical Biochemistry, 44(13):1105-9.
Boyne, A. F., Ellman, G. L. 1972. A methodology for analysis of tissue sulfhydryl components. Analytical Biochemistry, 46(2):639–653.
Burton, G. J., Jauniaux E. 2011. Oxidative stress. Best Practice & Research: Clinical Obstetrics & Gynaecology., 25(3):287-299.
Chikezie, P. C., Ojiako, O.A., Ogbuji, A. C. 2015. Oxidative stress in diabetes mellitus. International Journal of Biological and Chemical Sciences, 9(3):92-109.
Cuffe, J. S. M., Xu, Z. C., Perkins, A. V. 2017. Biomarkers of oxidative stress in pregnancy complications. Biomarkers in Medicine, 11(3):295-306.
De Lucca, L., Gallarreta, F. M. P., Gonçalves, T. L. 2015. Oxidative stress markers in pregnant women with preeclampsia. American Journal of Medical and Biological Research, 3(3):68-73.
De Lucca, L., Rodrigues, F., Jantsch, L. B., Kober, H., Neme, W. S., Gallarreta, F. M. P., Gonçalves, T. L. 2016. Delta-aminolevulinate dehydratase activity and oxidative stress markers in preeclampsia. Biomedicine & Pharmacotherapy, 84:224-9.
Dirar, A. M., Doupis, J. 2017. Gestacional diabetes from A to Z. World Journal of Diabetes, 8(12):489-511.
Galley, H. F., Davies, M. J., Webster, N. R. 1996. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radical Biology & Medicine, 20(1):139-43.
Gonçalves, T. L., Erthal, F., Corte, C. L., Müller, L. G., Piovezan, C. M., Nogueira, C. W., Rocha, J. B. 2005. Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women. Clinical Biochemistry, 38(12):1071-5.
Hastie, R., Lappas, M. 2014. The effect of pre-existing maternal obesity and diabetes on placental mitochondrial content and electron transport chain activity. Placenta, 35(9):673-83.
Hospital Universitário de Santa Maria. 2015.Clinical Protocol - Diabetes Mellitus in Gestation. Code PC11 DMG. Santa Maria. 18 p.
Jacques-Silva, M. C., Nogueira, C. W., Broch, L. C., Flores, E. M. M., Rocha, J. B. T. 2001. Dyphenyl disselenide and ascorbic acid changes deposition of selenium and acid ascorsbic in liver brain of mice. Pharmacology & Toxicology, 88(3):119–25.
Lambert, K., Holt, R. I. G. 2013. The use of insulin analogues in pregnancy. Diabetes, Obesity and Metabolism, 15(10):888-900.
Lapenna, D., Ciofani, G., Pierdomenico, S. D., Giamberardino, M. A., Cuccurullo, F. 2001. Reaction conditions affecting the relationship between thiobarbituric acid reactivity and lipid peroxides in human plasma. Free Radical Biology & Medicine, 31(3):331–5.
López-Tinoco, C. L., Roca, M., García-Valero, A., Murri, M., Tinahones, F. J., Segundo, C., Bartha, J. L., Aguilar-Diosdado, M. 2013. Oxidative stress and antioxidant status in patients with late-onset gestational diabetes mellitus. Acta Diabetologica, 50(2):201-8.
Murthy, K. A. S., Bhandiwada, A., Chandan, S. L., Gowda, S. L., Sindhusree, G. 2018. Evaluation of oxidative stress and proinflamatory cytokines in gestational diabetes mellitus and their correlation with pregnancy outcome. Indian Journal of Endocrinology and Metabolism, 22(1):79-84.
Palma, H. E., Wolkmer, P., Gallio, M., Corrêa, M. M., Schmatz, R., Thomé, G. R., Pereira, L. B., Castro, V. S., Pereira, A. B., Bueno, A., de Oliveira, L. S., Rosolen, D., Mann, T. R., de Cecco, B. S., Graça, D. L., Lopes, S. T. A., Mazzanti, C. M. A. 2014. Oxidative stress parameters in blood, liver, and kidney of diabetic rats treated with curcumin and/or insulin. Molecular and Cellular Biochemistry, 386(1-2):199-210.
Pescosolido, N., Campagna, O., Barbato, A. 2014. Diabetic retinopathy and pregnancy. International Ophthalmology, 34(4):989-997.
Polachini, C. R., Spanevello, R. M., Zanini, D., Baldissarelli, J., Pereira, L. B., Schetinger, M. R., da Cruz, I. B., Assmann, C. E., Bagatini, M. D., Morsch, V. M. 2016. Evaluation of delta-aminolevulinic dehydratase activity, oxidative stress biomarkers, and vitamin D levels in patients with multiple sclerosis. Neurotoxicity Research, 29(2):230-42.
Rajdl, D., Racek, J., Steinerová, A., Novotný, Z., Stozický, F., Trefil, L., Siala, K. 2005. Markers of oxidative stress in diabetic mothers and their infants during delivery. Physiological Research, 54(4):429-36.
Rodrigues, F., De Lucca, L., Neme, W. S., Gonçalves, T. L. 2018. Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers. Redox Report, 23(1):63-7.
Rueangdetnarong, H., Sekararithi, R., Jaiwongkam, T., Kumfu, S., Chattipakorn, N., Tongsong, T., Jatavan, P. 2018. Comparisons of the oxidative stress biomarkers levels in gestational diabetes mellitus (GDM) and non-GDM among Thai-population: cohort study. Endocrine Connection, 7(5):681-7.
Sahbaz, A., Cicekler, H., Aynioglu, O., Isik, H., Ozmen, U. 2016. Comparison of the predictive value of plateletcrit with various other blood parameters in gestational diabetes development. Journal of Obstetrics Gynaecology, 36(5):589-93.
Sato, T., Sugiyama, T., Kurakata, M., Saito, M., Sugawara, J., Yaegashi, N., Sagawa, N., Sanaka, M., Akazawa, S., Anazawa, S., Waguri, M., Sameshima, H., Hiramatsu, Y., Toyoda, N. 2014. Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study Japan. Endocrine Journal, 61(8):759-764.
Shang, M., Zhao, J., Yang, L., Lin, L. 2015. Oxidative stress and antioxidant status in women with gestational diabetes mellitus diagnosed by IADPSG criteria. Diabetes Research and Clinical Practice, 109(2):404-10.
Sociedade Brasileira de Diabetes. 2017. Guidelines of the Brazilian Diabetes Society 2017-2018. São Paulo: Clannad, 383 p.
Souza, J. B., Rocha, J. B. T., Nogueira, C. W., Borges, V. C., Kaizer, R. R., Morsch, V. M., Dressler, V. L., Martins, A. F., Flores, E. M. M., Schetinger, M. R. C. 2007. Delta-aminolevulinate dehydratase (δ-ALA-D) activity in diabetes and hypothyroidism. Clinical Biochemistry, 40(5-6):321-5.
Sugiyama, T., Saito, M., Nishigori, H., Nagase, S., Yaegashi, N., Sagawa, N., Kawano, R., Ichihara, K., Sanaka, M., Akazawa, S., Anazawa, S., Waguri, M., Sameshima, H., Hiramatsu, Y., Toyoda, N. 2014. Comparison of pregnancy outcomes between women with gestational diabetes and overt diabetes first diagnosed in pregnancy: a retrospective multi-institutional study in Japan. Diabetes Research and Clinical Practice, 103(1):20-5.
Toljic, M., Egic, A., Munjas, J., Orlic, N. K., Milovanovic, Z., Radenkovic, A., Vuceljic, J., Joksic, I. 2017. Increased oxidative stress and cytokinesis-block micronucleus cytome assay parameters in pregnant women with gestational diabetes mellitus and gestational arterial hypertension. Reprodutive Toxicology, 71:55-62.
Witczak, M., Wilczyńskic, J., Gulczyńskab, E., Talarb, T., Mordalskaa, A., Łopaczyńskaa, D., Ferenca, T. 2017.What is the impact of gestational diabetes mellitus on frequency of structural chromosome aberrations in pregnant women and their offspring? Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 818:27-30.
Zanini, D., Pelinson, L. P., Schmatz, R., Pereira, L. B., Martins, C. C., Baldissareli, J., Amaral, G. P., Soares, F. A. A., Reetz, L. G. B, Araújo, M. C., Chiesa, J., Morsch, V. M., Leal, D. B. R., Schetinger, M. R. 2014. δ-aminolevulinate dehydratase activity in lung cancer patients and its relationship with oxidative stress. Biomedicine & Pharmacotherapy, 68(5):603-9.
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How to Cite
Bernasconi, T., Lopes de Paula, H., Rodrigues, F. ., de Lucca, L., Ana Vendrame, S., & Santos Neme, W. . (2020). Delta-aminolevulinate dehydratase activity and oxidative profile in pregnant women with pre-gestational type 2 diabetes and gestational diabetes. International Journal for Innovation Education and Research, 8(1), 220-231. https://doi.org/10.31686/ijier.vol8.iss1.2154
