Synthesis, characterization and antimicrobial evaluations of mixed ligand complexes of sulphamethaxole and metronidaxole with some transistion metals (Zn, Co, Cu and Fe) in water methanol medium
DOI:
https://doi.org/10.31686/ijier.vol9.iss8.3067Keywords:
Sulfamethoxazole, Metronidazole, Antimicrobial, Metal complexes and Spectroscopic studyAbstract
Sulfamethoxazole and metronidazole are antibiotics use for the treatment of various bacterial infections. Their use as ligand is very prominent in formation of metal complexes. The transition metal complexes are synthesized by reaction of Sulfamethoxazole and metronidazole with metals such Mn(II), Cu(II), Fe(II) and Ni(II). The synthesized metal complexes are tested as antibacterial and antifungal. The antimicrobial activity of the complexes displays good potency against some microorganism such as Xanthomonas axonopodis, Streptococcus faecalia, Salmonella entrica, Claribacter michiganense, Xanthomonas phaseolin for bacteria and S.roofisii, M.phonoides, C.lindimuthianum for the fungi, it is revealed that all copper complexes show stronger antibacterial activity than the free drugs. The spectroscopic properties of the complexes were investigated using UV/visible and FT-IR which show metal-charge from 3d to 3s transition in which the transition state shows that they are octahedral geometry and their coordination site respectively. Their percentage yield was moderately high and producible. The complexes synthesized have higher inhibitory activities than the free ligand. The drug resistance in microbes is resulting in the incompetence of available drugs to care for the infections. The thermal analysis shows that the complexes are stable.
Downloads
References
Pelfrene, E., Botgros, R. & Cavaleri, M. Antimicrobial multidrug resistance in the era of COVID-19: a forgotten plight?. Antimicrob Resist Infect Control 10, 21 (2021). https://doi.org/10.1186/s13756-021-00893-z DOI: https://doi.org/10.1186/s13756-021-00893-z
Adediji, J.F. and J.A. Obaleye, 2012. Co (II) Complex of Mefloquine Hydrochloride: Synthesis, antimicrobial potential, antimalaria and toxicological Activities. E-Journal of Chemistry, 9(4): 2245-2254. DOI: https://doi.org/10.1155/2012/940258
P. Kumar, S. Gorai, M.K. Santra, B. Mondal, D. Manna, Dalton Trans. 41 (2012) 7573–7581 DOI: https://doi.org/10.1039/c2dt30232b
Dhumwad, S.D., Gudasi, K.B., and Goudar, T.R., IndianJ. Chem., 1995, vol. 34A, no. 1, p. 38
Masters, P.A., O’Bryan, T.A., Zurlo, J., Miller, D. Q and Joshi,N. (2003). Trimethoprim-Sulfamethoxazole Revisited. Archives of Internal Medicine, 163: 403-410. DOI: https://doi.org/10.1001/archinte.163.4.402
Helio, G. B., Rosalia, A., Clarissa, P. F., Nilo, Z and Marcos, A.P. M. (2006). Recent advances in the chemistry of 1,10-phenethrolines and their metal complex derivatives: synthesis and promising applications in medicine. Technology and Catalysis,19:1-3.
Bamigboye, M.O.,Obaleye, J.A and Abdulmolib, S. (2012). Synthesis, characterization and antimicrobial activity of some mixed sulfamethoxazole-cloxacillin metal drug complexes. International Journal of Chemistry, 22(2): 105-108
Z.Guo, P.J Sadler. Metals in medicine. Angewandte chemie international,38(11) DOI: https://doi.org/10.1002/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y
(1999)1512-1531.
S.S. Ashah, G.Rivera, Ashfaq. M. Recent advances in medicinal chemistry of
sulfonamides. Rational design as anti-tumoural, antibacterial and anti-inflammatory agents. Mini Rev Med Chemistry,13(1): (2013)70-86 DOI: https://doi.org/10.2174/138955713804484749
S. Demirayaka, A.Ç. Karaburuna, N. Kiraz, Synthesis and antibacterial activities of some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives, Eur. J. Med. Chem. 34 (1999) 275-278 DOI: https://doi.org/10.1016/S0223-5234(99)80062-2
D. Menendez, E. Rojas, L.A. Herrera, M.C. Lopez, M. Sordo, G. Elizondo,P. Ostrosky-
Wegman, DNA breakage due to metronidazole treatment, Mutat.Res. 478 (2001) 153-158 DOI: https://doi.org/10.1016/S0027-5107(01)00136-1
J.A. Driscoll, S. L. Brody and M.H. Kollef, Drugs, 2007, 67,351 DOI: https://doi.org/10.2165/00003495-200767030-00003
Gordon, A. T., Abosede, O. O., Ntsimango, S., Vuuren, S.V., Hosten, E. C., & Ogunlaja, A. S. (2020). Synthesis, characterization, molecular docking and antimicrobial activity of copper(II) complexes of metronidazole and 1,10 phenanthroline. Inorganica Chimica Acta, 510, 119744. doi: https://doi.org/10.1016/j.ica.2020.119744 DOI: https://doi.org/10.1016/j.ica.2020.119744
Tella, A. C., Shamle, N. J., Obaleye, J. A., Whitwood, A. C., Bourne, S. A., & Ajibade, P. A. (2020). Synthesis, characterization, crystal structures and electrochemical properties of heteroleptic Cu(II), Mn(II) and Zn(II) complexes of metronidazole with benzoic acid derivatives. Journal of Molecular Structure, 1209, 127925. doi: https://doi.org/10.1016/j.molstruc.2020.127925 DOI: https://doi.org/10.1016/j.molstruc.2020.127925
Jarrahpour, A.A., Motamedifar, M., Pakshir, K., Hadi, N. and Zarei, M.; (2004).Molecules, 9, 815 DOI: https://doi.org/10.3390/91000815
Joshi, K.R., Pandya, J.H. and Rojivadiya, A.J.; ICAIJ, 4 (3), 110 (2009).
Eugene-Osoikhia (Nee Adebesin), T. T., Aleem, A., & Ayeni, F. (2020). Synthesis,
characterization and antimicrobial studies of mixed ligands metal (ii) complexes of sulfamethoxazole and n,n- donors heterocycles. fudma journal of sciences, 4(2), 217 - 232. https://doi.org/10.33003/fjs-2020-0402-179. DOI: https://doi.org/10.33003/fjs-2020-0402-179
Beyramabadi, S.A., H. Eshtagh-Hosseini, M.R Housaindokht and A. Morsali, 2011. Synthesis, experimental and theoretical characterization of Cu (II) complex of 2-chloropyrimidine. Sci. Res. Ess., 6(20): 4341-4346. DOI: https://doi.org/10.5897/SRE10.423
Gulcan, M., M Sonmez and I. Berber, (2012). Synthesis, characterization and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II) and Pd (II) complexes. Turkey Journal of Chemistry, 36:189-200. DOI: https://doi.org/10.3906/kim-1104-2
Reddy, P.R and A.M. Reddy, 2000. Synthesis and characterization of mixed ligand Complexes of Ni(II), Cu(II) and Co(II) with pyrimidine nucleoside and amino acid. Indian Academy of science (Chem.Sci), 112(6): 593-600 DOI: https://doi.org/10.1007/BF02704366
Ogwuegbu Martin, O., Kenechukwu, E. C., Stanley, O. C., Patricia, E. N., & Ebere, E. C.(2019) Stoichiometric Determination of Fe (II), Ni (II) and Cu (II) Complexes of Metronidazole.
Kunkely H. and Vogler A. (2006).Photoproperties of Silver Sulfadiazine. Inorganic Chem. Commun. Vol. 10, Pg. 226-228. DOI: https://doi.org/10.1016/j.inoche.2006.08.025
Naeimi H. and Moradian M. (2009).Synthesis and Characterizatiion of Nitro-Schiff Bases Derived from 5-nitro-salicylaldehyde and Various Diaminesand their Complexes of Co (II), J. Coord. Chem. Vol.62, Pg.156- 160. DOI: https://doi.org/10.1080/00958970903225866
Ogunniran, K.O., Ajanaku, K.O., James, O.O .,Ajani, O.O., Adekoya, J.A (2008). Synthesis, characterization, antimicrobial activity and toxicology study of some metal complexes of mixed antibiotics. African Journal of Pure and Applied Chemistry. 2 (7), 69 – 74.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Suleiman A. Olagboye, Blessing John Bamisaye, Jerome Femi Adesugba
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyrights for articles published in IJIER journals are retained by the authors, with first publication rights granted to the journal. The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author for more visit Copyright & License.
How to Cite
Accepted 2021-04-11
Published 2021-08-01