Experimental Models in Rheumatoid Arthritis:
A Systematic Review using the IRAMUTEQ software
DOI:
https://doi.org/10.31686/ijier.vol8.iss1.2129Keywords:
Rheumatoid arthritis, Experimental models, IRAMUTEQ, Content analysisAbstract
Rheumatoid arthritis is an autoimmune and chronic pathological condition characterized by an inflammatory process of the joints It is a complex and multifactorial, involving genetic, epigenetic and environmental factors and the use of experimental models is required to better understand its pathology and for drug testing. The aim of this study was to perform a systematic literature review on experimental models in rheumatoid arthritis using IRAMUTEQ, a software that analysis, qualitatively and quantitatively, text fragments, as a methodological tool. After searching for articles published in the last five years on Scopus database and applying the exclusion criteria, we ended with 84 articles. The most commonly employed experimental models was the arthritis induction by inoculation of the Complete Freund's Adjuvant (CFA), followed by the use of combined methodologies and the collagen-induced arthritis (CIA). The analyses of abstracts by the IRAMUTEQ software provided a classification according to their textual elements in four classes, which were grouped into three main themes: in vivo models (class 1), clinical practice and traditional medicine (classes 2 and 3) and in vitro models (class 4) and it was also possible to build a similarity tree of the terms present in the abstracts and a word cloud with the most cited terms. Thus, the use of the IRAMUTEQ software as a methodological tool has been satisfactory, since it was possible to identify the main experimental models used, keywords, pathological processes and molecules involved in the pathogenesis of rheumatoid arthritis free of the researchers’ bias, in addition to being a tool for visual and intuitive results.
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References
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[15] K. M. Shah, P. Dadhaniya, V. R. Trived, Effect of caffeine in experimental model of rheumatoid arthritis in rats, International Journal of Pharmacology and Pharmaceutical Sciences 7 (3) (2015), pp. 364-67.
[16] F. Sultana, M. Rasool, A novel therapeutic approach targeting rheumatoid arthritis by combined administration of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin with reference to pro-inflammatory cytokines, inflammatory enzymes, Rankl and transcription factors, Chemico-Biological Interactions. 230 (2015), pp. 58-70.
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[19] A. B. Gómez-Sanmiguel, A. I. Martín, M. P. Nieto-Bona, C. Fernández-Galaz, M. A. Villanúa, A. López-Calderón, The melanocortin receptor type 3 agonist d-Trp(8)-γMSH decreases inflammation and muscle wasting in arthritic rats, Journal of Cachexia, Sarcopenia and Muscle. 7 (1) (2016b), pp. 79-89.
[20] G. Palma Zochio Tozzato, E. F. Taipeiro, M. A. Spadella, P. Marabini Filho, M. R. de Assis, C. P. Carlos, A. P. Girol, A. B. Chies, Collagen-induced arthritis increases inducible nitric oxide synthase not only in aorta but also in the cardiac and renal microcirculation of mice, Clinical and Experimental Immunology. 183 (3) (2016), pp. 341-349.
[21] J. Rovenský, M. Stančíková, E. Rovenská, S. Štvrtina, V. Štvrtinová, K. Švík, Treatment of rat adjuvant arthritis with flavonoid (detralex), methotrexate and their combination, Rheumatologia. 30 (4) (2016), pp. 113-118.
[22] A. Stofkova, K. Krskova, S. Vaculin, J. Jurcovicova, Enhanced activity of hormone sensitive lipase (HSL) in mesenteric but not epididymal fat correlates with higher production of epinephrine in mesenteric adipocytes in rat model of cachectic rheumatoid arthritis, Autoimmunity. 49 (4) (2016), pp. 268-276.
[23] J. Yang, H. D. Cai, Y. L. Zeng, Z. H. Chen, M. H. Fang, Y. P. Su, H. H. Huang, Y. Xu, C. X. Yu, Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats, Journal of Natural Products. 79 (10) (2016), pp. 2635-2643.
[24] Romero-Sánchez, C. Rodríguez, P. Santos-Moreno, A. M. Mesa, G. I. Lafaurie, S. Giraldo-Q, J. De-Avila, D. M. Castillo, M. Duran, P. Chalem Ch, J. M. Bello Gualtero R. Valle-Oñate, Is the treatment with biological or non-biological DMARDS a modifier of periodontal condition in patients with rheumatoid arthritis?, Current Rheumatology Reviews. 13 (2) (2017), pp. 139-151.
[25] P. V. G. Alabarse, P. S. Lora, J. M. S. Silva, R. C. E. Santo, E. C. Freitas, M. S. de Oliveira, A. S. Almeida, M. Immig, V. O. N. Teixeira, L. I. Filippin, R. M. Xavier, Collagen-induced arthritis as an animal model of rheumatoid cachexia, Journal of Cachexia, Sarcopenia and Muscle. 9 (3) (2018), pp. 603-612.
[26] I. M. Irmler, P. Gebhardt, B. Hoffmann, T. Opfermann, M. T. Figge, H. P. Saluz, T. Kamradt, 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis, Arthritis Research and Therapy. 16 (4) (2014), R155.
[27] V. V. Costa, F. A. Amaral, F. M. Coelho, C. M. Queiroz-Junior, B. G. Malagoli, J. H. S. Gomes, F. Lopes, K. D. Silveira, D. Sachs, C. T. Fagundes, L. D. Tavares, V. Pinho, T. A. Silva, M. M. Teixeira, F. C. Braga, D. G. Souza, Lithothamnion muelleri treatment ameliorates inflammatory and hypernociceptive responses in antigen-induced arthritis in mice, PLoS ONE. 10 (3) (2015), e0118356.
[28] F. O'Valle, M. Peregrina, V. Crespo-Lora, P. Galindo-Moreno, M. Roman, M. Padial-Molina, F. Mesa, J. Aneiros-Fernandez, D. Aguilar, E. Gonzalez-Rey, M. Delgado, P. Hernandez-Cortes, Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis, BioMed Research International. 2015 (2015), 681456.
[29] A. D. Cook, C. Louis, M. J. Robinson, R. Saleh, M. A. Sleeman, J. A. Hamilton, Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation, Arthritis Research and Therapy. 18 (1) (2016), 287.
[30] J. S. Peng, S. Y. Chen, C. L. Wu, H. E. Chong, Y. C. Ding, A. L. Shiau C. R. Wang, Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p, Arthritis and Rheumatology. 68 (2) (2016), pp. 370-381.
[31] R. Totsuka, T. Kondo, S. Matsubara, M. Hirai, Y. Kurebayashi, Effects of VLA-1 blockade on experimental inflammation in mice, Kobe Journal of Medical Sciences. 62 (2) (2016), E27-E37.
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Copyright (c) 2020 Verônica Assalin Zorgetto-Pinheiro, Alexandre Meira de Vasconcelos, Rafael Sanaiotte Pinheiro, Danielle Bogo, Iandara Schettert Silva
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Zorgetto-Pinheiro, V. A. ., Vasconcelos, A. M. de ., Pinheiro, R. S. ., Bogo, D. ., & Silva, I. S. . (2020). Experimental Models in Rheumatoid Arthritis:: A Systematic Review using the IRAMUTEQ software. International Journal for Innovation Education and Research, 8(1), 119-134. https://doi.org/10.31686/ijier.vol8.iss1.2129
