Lavender as treatment of Alzheimer's disease: literature review

Sheila Nedel; Jerônimo Branco; Carina Boeck; Aline Ferreira Ourique

doi:10.31686/ijier.vol8.iss12.2863

Authors

Sheila Nedel Universidade Franciscana
Jerônimo Branco Universidade Franciscana
Carina Boeck Universidade Franciscana
Aline Ferreira Ourique Universidade Franciscana

DOI:

https://doi.org/10.31686/ijier.vol8.iss12.2863

Keywords:

Dementia, Alzheimer's disease, Phytotherapy, Lavandula

Abstract

Neurodegenerative diseases affect the grey matter of the brain and secondarily the functions related to the white matter, with aging being one of the main responsible for their development. Among neurodegenerative diseases, dementia stands out, which has been considered by the World Health Organization (WHO) as a public health priority since 2012 due to its high prevalence. It is believed that degeneration of the cholinergic system in the hippocampus and cortex is closely related to cognitive deficits in dementia. Among the forms of treatment for dementia, aromatherapy stands out, which is part of phytotherapy and uses extracts and essential oils extracted from different organs of aromatic plants, and frequently administered via inhalation or topical application. Lavender is one of these plants and has traditionally been used to treat memory dysfunction. Thus, the present study sought to verify in the literature research using Lavandula as a form of treatment for neurodegenerative diseases, especially Alzheimer's disease. The search for the studies took place in January 2020, in the electronic database Web of Science. 42 articles were found, of which 13 adequately met the inclusion criteria. It can be concluded with this review, that both the extract and the essential oil of different lavender species have positive influences on memory formation, as well as on the improvement of cognitive function, especially in patients with Alzheimer's disease.

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References

Skovronsky DM, Lee VM, Trojanowski JQ. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annu Rev Pathol Mech, 2006; 1: 151-170. DOI: https://doi.org/10.1146/annurev.pathol.1.110304.100113

Sahium BMG, Silva SLG, Pereira SJP, Faria MM, Faria CC, RIBEIRO CAF. Revista RESU – Revista Educação em Saúde, 2015; 3, suplemento 1.

Tavares PAN, Negrão IPR, Lima RR. Predisposição às doenças neurodegenerativas durante o envelhecimento. Ver. Para. Medi., 2011; 25: 45.

Strohmeyer R, Rogers J. Molecular and cellular mediators of Alzheimer's disease inflammation. J Alzheimers Dis, 2001; 3 (1): 13 -157. DOI: https://doi.org/10.3233/JAD-2001-3118

Lahiri DK, Farlow MR, Greig NH, Sambamurti K. Current drug targets for Alzheimer's disease treatment. Drug Dev Res, 2002; 56 (3): 267-281. DOI: https://doi.org/10.1002/ddr.10081

Bourin M, Ripoll N, Dailly, E. Nicotinic receptors and Alzheimer's disease. Curr Med Res Opin, 2003; 19 (3): 169-177. DOI: https://doi.org/10.1185/030079903125001631

Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol, 2014; 88: 640-651. DOI: https://doi.org/10.1016/j.bcp.2013.12.024

Kashani MS, Tavirani MR, Talaei SA, Salami M. Aqueous extract of lavender (Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer’s disease. Neuroscience Bulletin, 2011; 27 (2): 99-106. DOI: https://doi.org/10.1007/s12264-011-1149-7

World Health Organization (WHO) (2013). Disponível em ˂http://apps.who.int/iris/bitstream/10665/95008/1/9789243506098_spa.pdf˃ [Consultado em 14/02/2019].

Organização Pan-Americana da Saúde (OPAS). Brasil e OPAS/OMS Demência: número de pessoas afetadas triplicará nos próximos 30 anos. 2017. Disponível em:https://www.paho.org/bra/index.php?option=com_content&view=article&id=5560:demencia-numero-de-pessoas-afetadas-triplicara-nos-proximos-30-anos&Itemid=839. Acesso em: 14 ago. 2019.

Celone KA, Calhoun VD, Dickerson BC, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: An independent componente analysis. J Neurosci, 2006; 26 (40): 10222-10231. DOI: https://doi.org/10.1523/JNEUROSCI.2250-06.2006

Rogers J.L., Kesner R.P. Cholinergic modulation of the hippocampus during encoding and retrieval of tone/shock-induced fear conditioning. Learn. Mem. 2004;11(1):102–107. DOI: https://doi.org/10.1101/lm.64604

Inestrosa NC, Alvarez A, Pérez C A, et al. Acetylcholinesterase accelerates assembly of amyloid- [beta]-peptides into Alzheimer's fi brils: Possible role of the peripheral site of the enzyme. Neuron, 1996; 16 (4): 881-891. DOI: https://doi.org/10.1016/S0896-6273(00)80108-7

Adsersen A, Gauguin B, Gudiksen L, Jager AK. Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity. J Ethnopharmacol, 2006; 104: 418-422. DOI: https://doi.org/10.1016/j.jep.2005.09.032

Jivad N, Rabiei Z. A review study on medicinal plants used in the treatment of learning and memory impairments. Asian Pacific Journal of Tropical Biomedicine, 2014; 4 (10) 780-789. DOI: https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0412

Oskouie AA, Yekta RF, Tavirani MR, Kashani MS, Goshadrou F. Effects on Rat Models of Alzheimer’s Disease Through the Investigation of Serum Metabolic Features Using NMR Metabolomics. Avicenna J of Medical Biotechnology, 2018; 8 (2): 4 – 10.

Lima, D. A. Tratamento Farmacológico da Doença de Alzheimer. Revista do Hospital Universitário Pedro Ernesto, n. 7, jan./jun., Rio de Janeiro, 2008.

Karlawish JHT, Casarett DJ, James BD, Xie SX, Kim SYH. The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology May, 2005: 64 (9):1514-1519. DOI: https://doi.org/10.1212/01.WNL.0000160000.01742.9D

Bagetta G, Cosentino M, Sakurada T, Prefácio em Aromaterapia: mecanismos básicos e uso clínico baseado em evidências. Oxfordshire, Reino Unido, 2016.

Dalilan S, Rezaei-Tavirani M, Nabiuni M, Heidari-Keshel S, Zamanian A, M., Zali H. Aqueous extract of Lavandula angustifolia inhibits lymphocytes proliferation of Hodgkin’s lymphoma patients. Iran J Cancer Prev, 2013: 6 (4): 201-208.

Khosravi-Boroujeni H, Mohammadifard N, Sarrafzadegan N, et al. Potato consumption and cardiovascular disease risk factors among Iranian population. Int J Food Sci Nutr, 2012; 8 (63): 13-20. DOI: https://doi.org/10.3109/09637486.2012.690024

Hajhashemi V, Ghannadi A., Sharif B. Anti-infl ammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol, 2003; 89 (1): 67-71. DOI: https://doi.org/10.1016/S0378-8741(03)00234-4

Valiollah H, Alireza G, Badie S. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J of Ethnopharmacology, 2003; 89: 67-71. DOI: https://doi.org/10.1016/S0378-8741(03)00234-4

Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Alibabaei Z, Shahrani M. The effect of pretreatment with different doses of Lavandula officinalis ethanolic extract on memory, learning and nociception. Biomed Aging Pathol, 2014; 4 (1): 71-76. DOI: https://doi.org/10.1016/j.biomag.2013.10.006

Li J, Wang C, Zhang JH, Cai JM, CAO YP, SUN XJ. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res, 2010; (1328): 152-161. DOI: https://doi.org/10.1016/j.brainres.2010.02.046

Lin PW, Chan WC, Ng, BF, Lam L.C. Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry, 2007; 22 (5): 405-410, DOI: https://doi.org/10.1002/gps.1688

Lehrner J, Marwinski G, Lehr S., Johren P, Deecke L. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiol Behav, 2005; 86 (1-2): 92-95. DOI: https://doi.org/10.1016/j.physbeh.2005.06.031

Chen MC, Fang SH, Fang L. The effects of aromatherapy in relieving symptomsrelated to job stress among nurses. Int J Nurs Pract, 2015; 21: 87-93. DOI: https://doi.org/10.1111/ijn.12229

Olapour A, Behaeen K, Akhondzadeh R, et al. The effect of inhalation of aromatherapy blend containing lavender essential oil on cesarean postoperative pain. Anesth Pain Med, 2013; (3): 203-207. DOI: https://doi.org/10.5812/aapm.9570

Velasco-Rodríguez R, Pérez-Hern´Andez MG, Maturano-Melgoza J. The effect of aromatherapy with lavender (Lavandula angustifolia) on serum melatonin levels. Complementary Therapies in Medicine, 2019; (47). DOI: https://doi.org/10.1016/j.ctim.2019.102208

Wang D, Yuan X, Liu T, et al. Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice. Molecules, 2012; 17: 9803-9817. DOI: https://doi.org/10.3390/molecules17089803

Jimbo D, Kimura Y, Taniguchi M, Inoue M, Urakami K. Effect of aromatherapy on patients with Alzheimer's disease. J Psychogeriatric Society, 2009; 9: 173-179. DOI: https://doi.org/10.1111/j.1479-8301.2009.00299.x

Hritcu L, Cioanca O, Hancianu M. Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats. Phytomedicine, 2012; 19 (6): 529-534. DOI: https://doi.org/10.1016/j.phymed.2012.02.002

Costa P, Gonçalves S, Valentão P, Andrade PB, Romano A. Accumulationof phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L’ Hér and their antioxidant and anti-cholinesterase potential. Food Chemistryand Toxicology, 2013; 57: 69-74. DOI: https://doi.org/10.1016/j.fct.2013.03.006

Hancianu M, Cioanca O, Mihasan M, Hritcu L. Neuroprotective effects of inhaled lavender oil on scopolamineinduced dementia via anti-oxidative activities in rats. Phytomedicine, 2013; 20 (5) 446-452. DOI: https://doi.org/10.1016/j.phymed.2012.12.005

Videira R, Castanheira P, Grãos M, Salgueiro L, Faro C, Cavaleiro C. A necrodane monoterpenoid from Lavandula luisieri essential oil as a cell-permeable inhibitor of BACE-1, the β-secretase in Alzheimer's disease. Flavour & Fragrance J, 2013; 28 (6):380-388. DOI: https://doi.org/10.1002/ffj.3156

Soheili M, Tavirani MR, Salami M. Lavandula angustifolia Extract Improves Deteriorated Synaptic Plasticity in an Animal Model of Alzheimer’s Disease. Iranian J. Basic Med. Sci., 2015; 18 (11): 1147-1152.

Zali H, Zamanian AM, Rezaei TM, Akbar ZBA. Protein drug targets of Lavandula angustifolia on treatment of rat Alzheimer᾽s disease. Iran J Pharm Res, 2015; 14 (1): 291-302.

Xu P, Wang K, Lu C, et al. The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice. Evidence-Based Complementary and Alternative Medicine, 2017; 2017: 11. DOI: https://doi.org/10.1155/2017/7426538

Mushtaq A, Anwar R, Ahmad M. Lavandula stoechas (L) a Very Potent Antioxidant Attenuates Dementia in Scopolamine Induced Memory Deficit Mice. Frontiers in Pharmacology, 2018; (9): 1375. DOI: https://doi.org/10.3389/fphar.2018.01375

Soheili M, Khalaji F, Mirhashemi M, Salami M. The Effect of Essential Oil of Lavandula angustifolia on Amyloid Beta Polymerization: An In Vitro Study. Iran J Chem Eng, 2018; 37 (6): 201-207.

Qneibi M, Jaradat N, Hawash M, et al. The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors. BioMed Research International, 2019; 2019: 11. DOI: https://doi.org/10.1155/2019/5640173

Soheili M, Tavirani MR, Salami M. Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia. Neuroscience & Medicine, 2012; 3 (4): 362-367. DOI: https://doi.org/10.4236/nm.2012.34044

Herman A, Tambor K, Herman A. Linalool Affects the Antimicrobial Efficacy of Essential Oils. Curr Microbiol, 2016; 72 (2): 165-172. DOI: https://doi.org/10.1007/s00284-015-0933-4

Ono K, Li L, Takamura Y, et al. Phenolic Compounds Prevent Amyloid Beta-Protein Oligomerization and Synaptic Dysfunction by SiteSpecific Binding. J Biol Chem, 2012; 287 (18): 14631- 14643. DOI: https://doi.org/10.1074/jbc.M111.325456