Review of Clinical Factors That Cause Acne Vulgaris

Zípora Santos; Maiara Velho; Fátima Zan; Virgínia Rech; Aline Ferreira Ourique

doi:10.31686/ijier.vol8.iss9.2659

Authors

Zípora Santos Universidade Franciscana
Maiara Velho Universidade Franciscana
Fátima Zan Instituto Federal Farroupilha, Santo Ângelo, Brazil.
Virgínia Rech Universidade Franciscana
Aline Ferreira Ourique Universidade Franciscana

DOI:

https://doi.org/10.31686/ijier.vol8.iss9.2659

Keywords:

skin disorder, pilosebaceous follicle, etiopathogenesis, pathophysiology

Abstract

Acne vulgaris is a common skin disorder caused by inflammation and/or blockage of the pilosebaceous follicle. This research is a literature review study that is descriptive in nature and seeks to compile information on the factors related to the etiopathogenesis of the clinical manifestations of acne vulgaris. A survey was conducted in the Web of Science database in the period from January to May 2019, using the keywords "acne vulgaris, etiopathogenesis and pathophysiology". The etiopathogenesis of acne vulgaris is multifactorial, but most studies list the following factors: like diet, daily habits, age, genetics, abnormalities in the production of sebum, follicular hyperkeratinization, increased colonization by Cutibacterium (formerly Probionibacterium) acnes, periglandular dermal inflammation, oxidative stress and immune reactions of the patient. Topical and/or systemic treatments for acne vulgaris, often includes retinoid-associated antibiotics. However, improper use of these can lead to bacterial resistance, in addition, it may trigger adverse effects at epidermis and dermis. The results obtained in this study are important in relation to the treatment of the pathogenesis of acne vulgaris. It is believed that this information - when analyzed together - can help with a better definition of the therapeutic protocol.

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Author Biographies

Zípora Santos, Universidade Franciscana

Laboratory of Nanotechnology
Maiara Velho, Universidade Franciscana

Laboratory of Nanotechnology
Fátima Zan, Instituto Federal Farroupilha, Santo Ângelo, Brazil.

Innovation and Technology Transfer Center
Virgínia Rech, Universidade Franciscana

Laboratory of Nanotechnology
Aline Ferreira Ourique, Universidade Franciscana

Professor Graduate Program in Nanosciences

References

Ahmad J, Gautam A, Komath S, Bano M, Garg A, Jain K. Topical Nano-emulgel for Skin Disorders: Formulation Approach and Characterization. Recent Pat Antiinfect Drug Discov. 2018;14(1):36–48. DOI: https://doi.org/10.2174/1574891X14666181129115213

Dréno, B., Pécastaings, S., Corvec, S., Veraldi, S., Khammari, A., Roques C. Cutibacterium acnes ( Propionibacterium acnes ) and acne vulgaris : a brief look at the latest updates. 2018;32:5–14. DOI: https://doi.org/10.1111/jdv.15043

Lertsatitthanakorn P, Taweechaisupapong S, Aromdee C, Khunkitti W. In vitro bioactivities of essential oils used for acne control. Int J Aromather. 2006;16(1):43–9. DOI: https://doi.org/10.1016/j.ijat.2006.01.006

Habeshian KA, Cohen BA. Current Issues in the Treatment of Acne Vulgaris. Pediatrics. 2020;145(Supplement 2):S225–30. DOI: https://doi.org/10.1542/peds.2019-2056L

Hsieh MF, Chen CH. Review: Delivery of pharmaceutical agents to treat acne vulgaris: Current status and perspectives. J Med Biol Eng. 2012;32(4):215–24. DOI: https://doi.org/10.5405/jmbe.901

dos Santos ZM, dos Santos MQ, Zancanaro V, Belaver EH, Nardi GM, Lafayet Gelinski JM, et al. Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema. NAUNYN-SCHMIEDEBERGS Arch Pharmacol. 2019;392(5):529–40. DOI: https://doi.org/10.1007/s00210-018-01604-z

Halvorsen JA, Lien L, Dalgard F, Bjertness E, Stern RS. Suicidal ideation, mental health problems, and social function in adolescents with eczema: A population-based study. J Invest Dermatol [Internet]. 2014;134(7):1847–54. Available at: http://dx.doi.org/10.1038/jid.2014.70 DOI: https://doi.org/10.1038/jid.2014.70

Samuels D V., Rosenthal R, Lin R, Chaudhari S, Natsuaki MN. Acne vulgaris and risk of depression and anxiety: A meta-analytic review. J Am Acad Dermatol [Internet]. 2020; Available at: https://doi.org/10.1016/j.jaad.2020.02.040 DOI: https://doi.org/10.1016/j.jaad.2020.02.040

Tasoula E, Gregoriou S, Chalikias J, Lazarou D, Danopoulou I, Katsambas A, et al. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece: results of a population survey. An Bras Dermatol. 2012;87(6):862–9. DOI: https://doi.org/10.1590/S0365-05962012000600007

Isaacsson VCS, Duquia RP, de Souza PRM, de Almeida HL, Breunig J de A. Dissatisfaction and acne vulgaris in male adolescents and associated factors. An Bras Dermatol. 2014;89(4):576–9. DOI: https://doi.org/10.1590/abd1806-4841.20142634

Jorgaqi E, Savo I, Koraqi A, Doci X, Cela R, Vasili E, et al. Efficacy of acne vulgaris treatment protocols according to its clinical forms. Dermatol Ther. 2020;(May). DOI: https://doi.org/10.1111/dth.13611

Sandru F et al. Treatment of acne vulgaris in relation to its etiopathogenesis. Rom J Med Pract. 2019;14(4):407–12. DOI: https://doi.org/10.37897/RJMP.2019.4.13

Costa A, Michalany NS, Alchorne MMA, Lima HC. Acne vulgar: Estudo piloto de avaliação do uso oral de ácidos graxos essenciais por meio de análises clínica, digital e histopatológica. An Bras Dermatol. 2007;82(2):129–34. DOI: https://doi.org/10.1590/S0365-05962007000200003

Lages RB, Bona SH, Silva FVM e, Gomes AKL, Campelo V. Acne fulminans successfully treated with prednisone and dapsone. An Bras Dermatol. 2012;87(4):612–4. DOI: https://doi.org/10.1590/S0365-05962012000400015

Gollnick HP, Bettoli V, Lambert J, Araviiskaia E, Binic I, Dessinioti C, et al. A consensus-based practical and daily guide for the treatment of acne patients. J Eur Acad Dermatology Venereol. 2016;30(9):1480–90. DOI: https://doi.org/10.1111/jdv.13675

Holland DB, Jeremy AHT. The role of inflammation in the pathogenesis of acne and acne scarring. Semin Cutan Med Surg. 2005;24(2):79–83. DOI: https://doi.org/10.1016/j.sder.2005.03.004

Costa a., Alchorne MM a., Goldschmidt MCB. Etiopathogenic features of acne vulgaris. An Bras Dermatol [Internet]. 2008;83(5):451–459. Available at: http://www.scielo.br/scielo.php?pid=S0365-05962008000500010&script=sci_arttext&tlng=es DOI: https://doi.org/10.1590/S0365-05962008000500010

Dessinioti C, Dreno B. Acne treatments: future trajectories. Clin Exp Dermatol. 2020;(March):1–7. DOI: https://doi.org/10.1111/ced.14239

Spagnolo E, Jéssica RM, Ceratti C, Spagnolo F, Adriana M, Asta D, et al. Efeitos da ação dos ácidos graxos na pele sadia por biometria cutânea * Action eff ects of fatty acids in healthy skin by skin biometry *. 2017;48–54.

Mills OH, Criscito MC, Schlesinger TE, Verdicchio R, Szoke E. in Acne Vulgaris. 2016;9(1):25–30.

Costa A, Lage D, Moisés TA. Acne and diet: truth or myth? An Bras Dermatol. 2010;85(3):346–53. DOI: https://doi.org/10.1590/S0365-05962010000300008

John R.Giudicessi, BA.Michael J.Ackerman. 2013. 基因的改变NIH Public Access. Bone [Internet]. 2008;23(1):1–7. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf

Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: Mechanisms of production and implications in disease. FASEB J. 2001;15(1):43–58. DOI: https://doi.org/10.1096/fj.99-1003rev

Alibardi L, Maderson PFA. Distribution of Keratin and Associated Proteins in the Epidermis of Monotreme , Marsupial , and Placental Mammals. 2003;66:49–66. DOI: https://doi.org/10.1002/jmor.10118

Jarrousse V, Castex-Rizzi N, Khammari A, Charveron M, Dréno B. Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytes. Arch Dermatol Res. 2007;299(9):441–7. DOI: https://doi.org/10.1007/s00403-007-0774-5

Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol. 2005;141(3):333–8. DOI: https://doi.org/10.1001/archderm.141.3.333

Ryu S, Han HM, Song PI, Armstrong CA, Park Y. Suppression of propionibacterium acnes infection and the associated inflammatory response by the antimicrobial peptide P5 in Mice. PLoS One. 2015;10(7):1–18. DOI: https://doi.org/10.1371/journal.pone.0132619

Vaz AL. Acne vulgar: Bases para o seu tratamento. Rev Port Med Geral e Fam [Internet]. 2003;19(6):561–70. Available at: http://www.rpmgf.pt/ojs/index.php?journal=rpmgf&page=article&op=view&path[]=9989

Bradley PP, Priebat D a, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. Vol. 78, The Journal of investigative dermatology. 1982. p. 206–9. DOI: https://doi.org/10.1111/1523-1747.ep12506462

Koreck A, Pivarcsi A, Dobozy A, Kemény L. The role of innate immunity in the pathogenesis of acne. Dermatology. 2003;206(2):96–105. DOI: https://doi.org/10.1159/000068476

Kim J, Ochoa M-T, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, et al. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J Immunol. 2002;169(3):1535–41. DOI: https://doi.org/10.4049/jimmunol.169.3.1535

Uchi H, Terao H, Koga T, Furue M. Cytokines and chemokines in the epidermis. J Dermatol Sci. 2000;24(SUPPL. 1):29–38. DOI: https://doi.org/10.1016/S0923-1811(00)00138-9

Campos ACL, Borges-branco A, Groth AK. Wound healing. Arq Bras Cir Dig [Internet]. 2007;20(1):51–8. Available at: http://www.scielo.br/pdf/abcd/v20n1/10.pdf DOI: https://doi.org/10.1590/S0102-67202007000100010

Shi VY, Leo M, Hassoun L, Chahal DS, Maibach HI, Sivamani RK. Role of sebaceous glands in inflammatory dermatoses. J Am Acad Dermatol [Internet]. 2015;73(5):856–63. Available at: http://dx.doi.org/10.1016/j.jaad.2015.08.015 DOI: https://doi.org/10.1016/j.jaad.2015.08.015

McInturff JE, Kim J. The role of toll-like receptors in the pathophysiology of acne. Semin Cutan Med Surg. 2005;24(2):73–8. DOI: https://doi.org/10.1016/j.sder.2005.03.002

Saleem M, Afaq F, Adhami VM, Mukhtar H. Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene. 2004;23(30):5203–14. DOI: https://doi.org/10.1038/sj.onc.1207641

Auffret N. Pathophysiological advances in acne. Ann Dermatol Venereol [Internet]. 2010;137(SUPPL. 2):S52–6. Available at: http://dx.doi.org/10.1016/S0151-9638(10)70025-9 DOI: https://doi.org/10.1016/S0151-9638(10)70046-6

Nagy I, Pivarcsi A, Kis K, Koreck A, Bodai L, McDowell A, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect. 2006;8(8):2195–205. DOI: https://doi.org/10.1016/j.micinf.2006.04.001

Fan E, Zhang L, Jiang S, Bai Y. Beneficial effects of resveratrol on atherosclerosis. J Med Food. 2008;11(4):610–4. DOI: https://doi.org/10.1089/jmf.2007.0091

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and temporal diversity of the human skin microbiome.Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., … Segre, J. A. (2009). Topographical and temporal diversity of the human skin microbiome. Science (New York, N. Science [Internet]. 2009;324(5931):1190–2. Available at: http://www.sciencemag.org.libproxy.mit.edu/content/324/5931/1190.full DOI: https://doi.org/10.1126/science.1171700

Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009;18(10):821–32. DOI: https://doi.org/10.1111/j.1600-0625.2009.00890.x

Gallitano SM, Berson DS. How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem. Int J Women’s Dermatology [Internet]. 2018;4(1):12–7. Available at: https://doi.org/10.1016/j.ijwd.2017.10.004 DOI: https://doi.org/10.1016/j.ijwd.2017.10.004

Neto EMR, Bruna K, Torres N, Junior FJG. Abordagem terapêutica da acne na clínica farmacêutica Therapeutic approach of acne in pharmaceutical clinic. 2015;59–66.

Nakatsuji T, Kao MC, Fang J, Zouboulis CC, Gallo RL, Huang C. NIH Public Access. October. 2009;129(10):2480–8. DOI: https://doi.org/10.1038/jid.2009.93

Sarici G, Cinar S, Armutcu F, Alt C, Koca R, Tekin NS. Oxidative stress in acne vulgaris. 2010;763–7. DOI: https://doi.org/10.1111/j.1468-3083.2009.03505.x

Morganti P, Berardesca E, Guarneri B, Guarneri F, Fabrizi G, Palombo P, et al. Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: A multicentre-randomized trial. Int J Cosmet Sci. 2011;33(5):467–76. DOI: https://doi.org/10.1111/j.1468-2494.2011.00658.x

Ig OR, Ar I. Antioxidant activity , lipid peroxidation and skin diseases . What ’ s new. 2003;663–9. DOI: https://doi.org/10.1046/j.1468-3083.2003.00751.x

Ottaviani M, Camera E, Picardo M. Lipid mediators in acne. Mediators Inflamm. 2010;2010. DOI: https://doi.org/10.1155/2010/858176

Ottaviani M, Alestas T, Flori E, Mastrofrancesco A, Zouboulis CC, Picardo M. Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: A possible role in acne vulgaris. J Invest Dermatol. 2006;126(11):2430–7. DOI: https://doi.org/10.1038/sj.jid.5700434

dos Santos ZMQ, dos Santos MQ, Zancanaro V, Bellaver EH, Nardi GM, Gelinski JML, et al. Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema. Naunyn Schmiedebergs Arch Pharmacol. 2019;392(5):529–40. DOI: https://doi.org/10.1007/s00210-018-01604-z

Arican O, Kurutas EB, Sasmaz S. Oxidative stress in patients with acne vulgaris. Mediators Inflamm. 2005;2005(6):380–4. DOI: https://doi.org/10.1155/MI.2005.380

Matar A, EL Samahy M, Hassen S, EL-Khazragy N. Effect of Intense Pulsed Light on Oxidative Stress in Acne Vulgaris. J Recent Adv Med. 2020;1(1):14–9. DOI: https://doi.org/10.21608/jram.2019.14041.1014

Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol [Internet]. 2006;126(12):2565–75. Available at: http://dx.doi.org/10.1038/sj.jid.5700340 DOI: https://doi.org/10.1038/sj.jid.5700340

Al-shobaili HA. Oxidants and Anti-Oxidants Status in Acne Vulgaris Patients with Varying Severity. 2014;44(2):202–7.

Grange PA, Chéreau C, Raingeaud J, Nicco C, Weill B, Dupin N, et al. Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. PLoS Pathog. 2009;5(7). DOI: https://doi.org/10.1371/journal.ppat.1000527

Bengtsson, Lundberg M, Avila-Cariño J, Jacobsson G, Holmgren A, Scheynius A. Thiols decrease cytokine levels and down-regulate the expression of CD30 on human allergen-specific T helper (Th) 0 and Th2 cells. Clin Exp Immunol. 2001;123(3):350–60. DOI: https://doi.org/10.1046/j.1365-2249.2001.01453.x

Fridovich I. Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen? Ann N Y Acad Sci. 1999;893:13–8. DOI: https://doi.org/10.1111/j.1749-6632.1999.tb07814.x

Kurutas EB, Arican O, Sasmaz S. Superoxide dismutase and myeloperoxidase activities in polymorphonuclear leukocytes in acne vulgaris. Acta Dermatovenerologica Alpina, Pannonica Adriat. 2005;14(2):39–42.

Eady E a, Cove JH. Is acne an infection of blocked pilosebaceous follicles? Implications for antimicrobial treatment. Am J Clin Dermatol. 2000;1(4):201–9. DOI: https://doi.org/10.2165/00128071-200001040-00001

Ikeno H, Tochio T, Tanaka H, Nakata S. Decrease in glutathione may be involved in pathogenesis of acne vulgaris. J Cosmet Dermatol. 2011;10(3):240–4. DOI: https://doi.org/10.1111/j.1473-2165.2011.00570.x

Zouboulis CC. Zileuton, a new efficient and safe systemic anti-acne drug. Dermatoendocrinol. 2009;1(3):188–92. DOI: https://doi.org/10.4161/derm.1.3.8368

Zouboulis CC, Seltmann H, Alestas T. Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. Exp Dermatol. 2010;19(2):148–50. DOI: https://doi.org/10.1111/j.1600-0625.2009.00929.x

Ribeiro B de M, Almeida LMC, Costa A, Francesconi F, Follador I, Neves JR. Etiopathogeny of acne vulgaris: a practical review for day-to-day dermatologic practice. Surg Cosmet Dermatology. 2015;7(3):20–6. DOI: https://doi.org/10.5935/scd1984-8773.2015731682

Degitz K, Placzek M, Borelli C, Plewig G. Pathophysiologie der akne. JDDG - J Ger Soc Dermatology. 2007;5(4):316–25. DOI: https://doi.org/10.1111/j.1610-0387.2007.06274_supp.x