ISP - IFRO SLICE PROTEIN
automatizing the process of protein fragments extraction
DOI:
https://doi.org/10.31686/ijier.vol10.iss11.3967Keywords:
three-dimensional structures, ligands, polypeptidesAbstract
Macromolecules are proteins formed by amino acids joined by peptide bonds, and can be described in different structural levels: primary, secondary, tertiary and quaternary. It’s possible to extract a small part of the three dimensional structure of the protein to be used as a ligand. However, the extraction of fragments by experimental methods is expensive and time-consuming. In this context, the development of a web service to extract fragments of three-dimensional proteins makes the process more assertive and less costly. The methods used for the development of the protein slicer web service were the Python programming language, and the Javascript, PHP and HTML languages are being used. And for the testing of the system, three-dimensional structures of proteins present in the RCSB Protein Data Bank (RCSB PDB) were used.
References
Alberts, Bruce, et al. Fundamentos da Biologia Celular-4. Artmed Editora, 2006.
Borges, Michelle Jayme. "Efeito da toxina botulínica tipo a no tratamento de espasticidade de pacientes com sequelas de AVC e sua influência na funcionalidade: meta-análise." (2018).
COLHADO, Orlando Carlos Gomes; BOEING, Marcelo; ORTEGA, Luciano Bornia. Toxina botulínica no tratamento da dor. Revista Brasileira de Anestesiologia, v. 59, p. 366-381, 2009. DOI: https://doi.org/10.1590/S0034-70942009000300013
de Mello Sposito, Maria Matilde. "Toxina Botulínica do Tipo A: mecanismo de ação." Acta fisiátrica 16.1 (2009): 25-37. DOI: https://doi.org/10.11606/issn.2317-0190.v16i1a103037
LODISH, H. et al. Biologia celular e molecular. 7. ed. Porto Alegre: Artmed, 2014.
Nelson, David L.; Cox, Michael M. Princípios de bioquímica de Lehninger. 5 ed. Porto Alegre: Artmed, 2011.
Oliveira, Lariza Laura de. Uso de estratégias baseadas em conhecimento para algoritmos genéticos aplicados à predição de estruturas tridimensionais de proteínas. Diss. Universidade de São Paulo, 2011.
RCSB PDB, RCSB Protein Data Bank: www.rcsb.org/.
Rino, José Pedro, e Nelson Studart. "Um potencial de interação para o estudo de materiais e simulações por dinâmica molecular." Química Nova 24.6 (2001): 838-845. DOI: https://doi.org/10.1590/S0100-40422001000600022
Silva, LX; Bastos, LL; Santos, LH. Modelagem computacional de proteínas. In: BIOINFO - Revista Brasileira de Bioinformática e Biologia Computacional. 1. Ed. Vol. 1. Lagoa Santa: Editora Alfahelix, 2021. DOI: 10.51780/978-6-599-275326. DOI: https://doi.org/10.51780/978-6-599-275326-08
Sposito MM de M. Toxina botulínica tipo A: propriedades farmacológicas e uso clínico. Acta Fisiátr. [Internet]. 14 de dezembro de 2004 [citado 28 de maio de 2022];11(Supl.1):S7-S44. Disponível em: https://www.revistas.usp.br/actafisiatrica/article/view/102495 DOI: https://doi.org/10.11606/issn.2317-0190.v11iSupl.1a102495
Wolynes, P.G. Evolution, Energy Landscapes and the Paradoxes of Protein Folding. Biochimie 2015, 119, 218–230. DOI: https://doi.org/10.1016/j.biochi.2014.12.007
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Dyuly Kelry Costa Guimarães, Micaely Raira Linhares de Araújo, Kethelin Vitória Zaire dos Santos, Henrique Lopes de Barros, Marcio Rodrigues Miranda, Kaio Alexandre da Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyrights for articles published in IJIER journals are retained by the authors, with first publication rights granted to the journal. The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author for more visit Copyright & License.
How to Cite
Accepted 2022-09-29
Published 2022-11-01
Most read articles by the same author(s)
- Kaio Alexandre da Silva, Object of Study of Literacy: a learning object based on mobile learning to aid in the process of child literacy , International Journal for Innovation Education and Research: Vol. 8 No. 11 (2020): International Journal for Innovation Education and Research
- Drielle da Guia Cintra Ribeiro, Artur Virgílio Simpson Martins, Kaio Alexandre da Silva, Ricardo Alves Oliveira, Jorge Washington de Amorim Junior, Higor Cordeiro de Souza, Esiomar Andrade Silva Filho, Alessandro Crispim Macedo, Raul Afonso Pommer Barbosa, Bibliometric Study , International Journal for Innovation Education and Research: Vol. 8 No. 2 (2020): International Journal for Innovation Education and Research
- Denise Dandara Gomes de Carvalho Severo, Iara Rodrigues Abreu, Welliton da Silva Belém, André Luiz Barbosa Marinho, Mateus Silva Gonçalves, Diana Ketlem Paula do Nascimento, Daniela Tissuya Silva Toda, Kaio Alexandre da Silva, OLYMPIAQUIZ , International Journal for Innovation Education and Research: Vol. 10 No. 1 (2022): International Journal for Innovation Education and Research
- Alberto Meireles Oliveira de Almeida, Marcio Rodrigues Miranda, Leonardo de Azevedo Calderon, Use Of the Open Journal System Platform , International Journal for Innovation Education and Research: Vol. 10 No. 9 (2022): International Journal for Innovation Education and Research
- Bruno Felipe da Silva, Kaio Alexandre da Silva, Luiz Francisco Machado Pfeifer, Human-computer interaction tests applied to the +LEITE app for android , International Journal for Innovation Education and Research: Vol. 10 No. 9 (2022): International Journal for Innovation Education and Research
- Micaely Linhares, Dyuly Kelry Costa Guimarães, Kethelin Vitória Zaire dos Santos, Henrique Lopes de Barros, Marcio Rodrigues Miranda, Kaio Alexandre da Silva, Ramachandran Chart , International Journal for Innovation Education and Research: Vol. 10 No. 12 (2022): International Journal for Innovation Education and Research