Meta-analysis: hydroxychloroquine therapy approach with or without azithromycin against covid-19
DOI:
https://doi.org/10.31686/ijier.vol8.iss8.2493Keywords:
Azithromycin, Covid-19, Hydroxychloroquine, SARS-CoV-2Abstract
Objective: identify and analyse the evidences about the use of hydroxychloroquine with or without azithromycin in covid-19. Methods: This is a systematic review with meta-analysis using posted articles in December 2019 until May 2020. The research was formulated by a question structured using PICO strategy, in these data bases: BVS, PUBMED, MEDLINE, LILACS, BDENF e SCIELO. Results and discussion: Resulted in 9 articles founded by the PRISMA, approaching 4182 patients. PICO strategy selected and analysed 5 articles projected in Forest plots. Resulting in tree clinical trials (RR: 1.15; IC95%, 0.76 a 1.73), which did not found big differences in the outcome in the groups of patients who used HCQ with or without AZT, comparing with the control group. Two studies analysed the number of deaths/intubations in comparative group, experimental group and control (RR:1.86; IC: 95%, 1.54 a 2.26) resulting in more chance of death /intubation in patients who used HCQ. Conclusion: It was found that is not possible to prove the efficacy of these drugs, due to the limited number of randomized and controlled clinical trials. Therefore, the encourage of scientific production about the HCQ and AZT against Covid-19 is more than necessary.
References
A.C.D. Lima, D.A. Cunha, R.C. Albuquerque, R.N.A. Costa, H.J. Silva, Alterações sensoriais em respiradores orais: revisão sistemática baseada no método prisma. Revista Paulista de Pediatria, 37(1), 97-103, 2019. DOI: https://doi.org/10.1590/1984-0462/;2019;37;1;00012
D. Sadigurskya, M.D. Sousa, Y.G.L. Cajaíba, R.R. Martins, D.M.V. Lobão. Profilaxia infecciosa com aplicação local de vancomicina em pó em cirurgias ortopédicas: revisão sistemática com metanálise. Revista brasileira de ortopedia, 54(6), 617-626, 13, 2019. DOI: https://doi.org/10.1016/j.rbo.2017.12.003
D.N. Juurlink, Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of sars-cov-2 infection. Can. Med. Association journal, 2020; 192: 450-453, 2020. DOI: https://doi.org/10.1503/cmaj.200528
E.S. Rosenberge, E.M. Dufort, T. Udo, L.A. Wilberschied, J. Kumar, J. Tesoriero, P. Weinberg, J. Kirkwood, A. Muse, J. DeHovitz, D.S. Blog, B. Hutton, David R Holtgrave, H.A. Zucker. association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with covid-19 in new york state, jama, e208630, 2020. DOI: https://doi.org/10.1001/jama.2020.8630
F. R. Bessière, H. Roccia, A. Delinière. Assessment of qt intervals in a case series of patients with coronavirus disease 2019 (covid-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit. Jama cardiol, e201787.Cognition. (2008). In Oxford reference online premium dictionary, 2020. DOI: https://doi.org/10.1001/jamacardio.2020.1787
J. Andreani, M. Bideau, I. Duflot, P. Jardot, C. Rolland, M. Boxberger, N. WurtzabIn, J.M. Rolain, P. Colson. B.L. Scola, D. Raoult. vitro testing of combined hydroxychloroquine and azithromycin on sars-cov-2 shows synergistic effect. Microbial pathogenesis, v.145, p.1-4, 2020. DOI: https://doi.org/10.1016/j.micpath.2020.104228
J. Chean, D. Liu, L. Liu, P. Liu, Q. Xu, L. Xia, Y. Ling, D. Huang, S. Song, D. Zhang, Z. Qian, T. Li, Y. Shen, H. Lu, A pilot study of hydroxychloroquine in the treatment of patients with common coronavirus-19 disease (covid-19), Zhejiang da xue xue bao.Yi xue ban, Journal of Zhejiang University. Medical sciences, 49(2), 215–21, 2020.
J. Geleris. Y. Sun, J. Platt, J. Zucker, M. Baldwin, G. Hripcsak, A. Labella, D.K. Manson, C. Kubin, R.G. Barr, M.E. Sobieszczyk, N.W. Schluger. Observational study of hydroxychloroquine in hospitalized patients with covid-19. The new england journal of medicine, 2012410. Advance online publication, 2020. DOI: https://doi.org/10.1056/NEJMoa2012410
J. Molina, C. Delaugerre, J. Le Goff, B. Mela-Lima, D. Ponscarme, L. Goldwirt, N. Castro. No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection. Medecine et maladies infectieuses, 50(4), 384, 2020. DOI: https://doi.org/10.1016/j.medmal.2020.03.006
M. Million, J.C. Lagier, P. Gautret, P. Colson, P.E. Fournier, S. Amrane, M. Hocquart, M. Mailhe, V. Esteves-Vieira, B. Doudier, C. Aubry, F. Correard, A. Giraud-Gatineau, Y. Roussel, C. Berenger, N. Cassir, P. Seng, C. Zandotti, C. Dhiver, I. Ravaux,… D. Raoult. Early treatment of 1061 covid-19 patients with hydroxychloroquine and azithromycin, marseille, France. Travel medicine and infectious disease, 101738, 2020. DOI: https://doi.org/10.1016/j.tmaid.2020.101738
P. Gautret., J.C. Lagier, P. Parola, V.T. Hoang, L. Meddeb, J. Sevestre, M. Mailhe, B. Doudier, C. Aubry, S. Amrane, P. Seng, M. Hocquart, C. Eldin, J. Finance, V. E. Vieira, H. T. Tissot-Dupont, S. S. Honoré, A. Million, M. Colson, D. Raoult, Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 covid-19 patients with at least a six-day follow up: a pilot observational study. Travel medicine and infectious disease, travel med infect dis, v.34 (101663): p.1-7, 2020. DOI: https://doi.org/10.1016/j.tmaid.2020.101663
P. Gautret., J.C. Lagier, P. Parola, V.T. Hoang, L. Meddeb, J. Sevestre, M. Mailhe, B. Doudier, C. Aubry, S. Amrane, P. Seng, M. Hocquart, C. Eldin, J. Finance, V. E. Vieira, H. T. Tissot-Dupont, S. S. Honoré, A. Million, P., Chabrière, E., La Scola, B., Rolain, J. M., Brouqui, P.D. Raoult, Hydroxychloroquine and azithromycin as a treatment of covid-19: results of an open-label non-randomized clinical trial, international journal of antimicrobial agents, v.20 (105949): 1-24, 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105949
P. Zhai., Y.X. Ding, J. Long, Y. Zhong, Y. Li. The epidemiology, diagnosis and treatment of COVID-19. International journal of antimicrobial agents, 55(5), 105955, 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105955
R.M. Lana, F.C. Coelho, M.F.C. Gomes, O.G. Cruz, L.S. Bastos, D.A.M. Villela, C.T. Codeço. Emergência do novo coronavírus (sars-cov-2) e o papel de uma vítima nacional em saúde e efetiva. Cafajeste. Saúde pública. 36 (3): 1-3, 2020. DOI: https://doi.org/10.1590/0102-311x00019620
S. J. S. Pacheco, S. Kong, P. P. Santacruz, R.W. Murphy, L. Kubatko. Median-joining network analysis of SARS-CoV-2 genomes is neither phylogenetic nor evolutionary. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12518–12519, 2020. DOI: https://doi.org/10.1073/pnas.2007062117
T. Strabelli, D.E. Uip. COVID-19 and the Heart. COVID-19 e o Coração. Arquivos brasileiros de cardiologia, 114(4), 598–600, 2020. DOI: https://doi.org/10.36660/abc.20200209
W. Tang, Z. Cao, M. Han, Z. Wang, J. Chen, W. Sun, Y. Wu, W. Xiao, S. Liu, E. Chen, W. Chen, X. Wang, J. Yang, J. Lin, Q. Zhao, Y. Yan, Z. Xie, D. Li, Y. Yang, L. Liu, J. Qu, G. Ning, G Shi, Q. Xie. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. The BMJ (Clinical research ed.), 369: m1849, 2020. DOI: https://doi.org/10.1136/bmj.m1849
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Josilene Nascimento do Lago, Cosmo de Sousa Costa, Larissa Emily de Carvalho Moraes, Raissa Ribeiro da Silva, Gleiciane Moraes Gonçalves, Thainar Stefanie Barbosa de Oliveira, Tatiane Roseli Alves Castro, Thalles Ricardo Melo de Souza, Christian Pacheco de Almeida, Lorena Victória de Souza Ferreira, Alex Jean Ferreira da Silva, Widson Davi Vaz de Matos, Renan Rocha Granato, Ademir Ferreira da Silva Júnior
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Copyrights for articles published in IJIER journals are retained by the authors, with first publication rights granted to the journal. The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author for more visit Copyright & License.
How to Cite
Accepted 2020-07-18
Published 2020-08-01
Most read articles by the same author(s)
- Phamela Ingrid de Jesus Ferreira, Bianca Maia de Lima, Izabel Silva Carvalho, Carla de Castro Sant' Anna, Marcella Kelly Costa de Almeida, Josilene Nascimento do Lago, Epidemiological profile of children infected with the Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome , International Journal for Innovation Education and Research: Vol. 9 No. 11 (2021): International Journal for Innovation Education and Research
- Leticia Nascimento Chagas, Josilene Nascimento do Lago, Beatriz Azevedo Pinheiro Nahum, Raimunda Josiane Rodrigues Freitas, Ana Paula Melo Martins, Competences of nurses in the Family Health Strategy: an integrative literature review , International Journal for Innovation Education and Research: Vol. 11 No. 3 (2023): International Journal for Innovation Education and Research