Perspectives of the use of sulforaphane in animal model of colorectal carcinogenesis in Brazil
a review
DOI:
https://doi.org/10.31686/ijier.vol7.iss12.2088Keywords:
Sulforaphane, Colonic Neoplasms, Rats, Azoxymethane, BroccoliAbstract
Colon cancer is a growing health problem in Brazil. According to data from the World Health Organization (WHO), colon cancer is among the top ten causes of mortality and morbidity in the world. Besides, the disease has a significant economic impact on the Brazilian public health system. Over the past five years, there has been an increased interest in use, isolation, characterization and determination of the biological actions of compounds such as broccoli. Experimental studies with genetically modified (GMOs) rats, mice, and rats using Sulforaphane have demonstrated their ability to prevent, delay and reverse pre-neoplastic lesions, improved survival, as well as acting on neoplastic cells with therapeutic action. Sulforaphane through activation of Nrf2 increases the activity of phase II enzymes such as glutathione S transferase (GST), which is involved in the elimination of xenobiotic compounds. Aberrant crypts are induced, in Wistar rats and mice, by genotoxic and non-genotoxic chemical compounds. Colon carcinogenesis is generally induced in rats and mice by two substances, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM). Azoxymethane is often used concerning DMH because it is more potent and requires few reactions for its activation. It is possible to conclude that Sulforaphane, through its various biological actions, presents efficiency in the prevention of colon cancer and significant potential for use in future experimental studies with genetically modified rats, mice, and rats.
References
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[31]. D.T.H. Verhoeven, H. Verhagen, R.A. Goldbohm, P.A. Van Den Bramdt, G. Van Poppe. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. ChemBiol Interact. 1997. v.103. n.79-129.
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[33]. C. Zhang, Z.Y. Su, T.O. Khor, L. Shu, A.N. Kong.Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. BiochemPharmacol. 2013. v.85. p.1398-404.
[2]. M.G.V. Gottlieb, D. Carvalho, R.H. Schneider, I.B.M. Cruz. Aspectos genéticos do envelhecimento e doenças associadas: uma complexa rede de interações entre genes e ambientes. Artigo Original. Rev. Bras. Geriatr. Gerontol. 2007. v.10. n.3. p. 273 – 283. http://www.scielo.br/pdf/rbgg/v10n3/1981-2256-rbgg-10-03-0273.pdf
[3]. C.N. Armah, M.H. Traka, J.R. Dainty, M. Defernez, A. Janssens, W. Leung, J.F. Doleman, J.F. Potter, and R.F. Mithen. A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function. Am J ClinNutr. 2013. v.98. n.3. p.712-722. DOI:10.3945/ajcn.113.065235
[4]. A. Bartolome, K. Mandap, K.J. David, F. Sevilla, J. Villanueva. SOS-red fluorescent protein (RFP) bioassay system for monitoring of antigen toxic activity in plant extracts. Biosensors & Bioelectronics. 2006. Volume 21, Issue 11, Pages 2114-2120. DOI: 10.1016/j.bios.2005.10.009
[5]. A.I. Amjad, R.A. Parikh, L.J. Appleman, E.R. Hahm, K. Singh, S.V. Singh. Broccoli-Derived Sulforaphane and Chemo prevention of Prostate Cancer: From Bench to Bedside. Curr Pharmacol Rep. 2015 Nov 1;1(6):382-390. DOI: 10.1007/s40495-015-0034-x
[6]. T.W. Kensler, P.A. Egner, S.A. Agyeman, K. Visvanathan, J.D. Groopman, J.G. Chen, T.Y. Chen, J.W. Fahey, P. Talalay. Keap1–Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane. Top Curr Chem. 2013. v.329. p.163–178. DOI: 10.1007/128_2012_339
[7]. P. SALES, B. PELEGRINI, M.C. GOERCH. Nutrigenomics: Definitions and Advances of this New Science. J NutrMetab. 2014. v.20. p.27-59. DOI: 10.1155/2014/202759
[8]. T.A. Shapiro, J.W. Fahey, K.L. Wade, K.K. Stephenson, P. Talalay. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev. 2001. 10, 501–508. PMID: 11352861
[9]. S.A. Stopera, J.R. Davie, R.P. Bird. Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in pre-neoplastic lesions in colon cancer. Carcinogenesis. 1992;13(4):573-8. DOI: 10.1093/carcin/13.4.573
[10]. M. Traka, A.V. Gasper, A. Melchini, J.R. Bacon, P.W. Needs, V. Frost, A. Chantry, A.M.E. Jones, C.A. Ortori, D.A. Barrett, R.Y. Ball, R.D. Mills, and R.F. Mithen. Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate. PLoS ONE. 2008. v.3. n.7. e2568. DOI: 10.1371/journal.pone.0002568
[11]. R.S. TUMA. Epigenetic therapies move into new territory, but how exactly do they work? J Natl Cancer Inst. 2009. v.101. n.19. p.1300–1. DOI: 10.1093/jnci/djp342
[12]. D.C. MALTA, J.B. SILVA JÚNIOR. O plano de ações estratégicas para o enfrentamento das doenças crônicas não transmissíveis no Brasil e a definição das metas globais para o enfrentamento dessas doenças até 2025: uma revisão. Artigo de Revisão. Epidemiologia. Serv. Saúde, Brasília, DF. 2013. v.22. n. 1. p.151 – 164. http://dx.doi.org/10.5123/S1679-49742013000100016
[13]. D.C. Malta, M. Lenildo, R.R. do Prado, J.C. Escalante, M.I. Schimidt, B.B Duncan. Mortalidade por doenças crônicas não transmissíveis no Brasil e suas regiões, 2000 a 2011. Artigo Original. Epidemiol. Serv. Saúde, Brasília, DF. 2014. v. 23. n. 4. p. 599 – 608. http://dx.doi.org/10.5123/S1679-49742014000400002.
[14]. E.S. Fiala. Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer. 1977. v.40. (5 Suppl). p.2436-45. DOI: 10.1002/1097-0142(197711)40:5+<2436::aid-cncr2820400908>3.0.co;2-u
[15]. R.H. Dashwood, M.C. Myzak, E. Ho. Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis. 2006. v.27. p.344–9. DOI: 10.1093/carcin/bgi253
[16]. K.M Camp, E. Trujillo. Position of the Academy of Nutrition and Dietetics: Nutritional Genomics. Journal of the Academy of Nutrition and Dietetics. 2014. v.114. n. 2. p. 299 – 312. DOI: 10.1016/j.jand.2013.12.006
[17]. B. Combourieu, L. Elfoul, A.M. Delort. Identification of new derivatives of sinigrin and glucotropaeolin produced by the human digestive microflora using (1) h-nmr spectroscopy analysis of in vitro incubations. Drug Metab. Dispos., 2001. v.29. p.1440–1445. PMID: 11602519
[18]. L. Elfoul, S. Rabot, N. Khelifa, A. Quinsac, A. Duguay, A. Rimbault. Formation of ally isothiocyanate from sinigrin in the digestive tract of rats mono-associated with a human colonic strain of Bacteroidesthetaiotaomicron. FEMS Microbiol. Lett. 2001. v.197. p.99–103. DOI: 10.1111/j.1574-6968.2001.tb10589.x
[19]. J.L. Fernández, J. Benito. Panorama actual de La Nutrigenómica: Esperanza o Realidad? Nutr.Clin. Diet. 2008. v. 28, n.3. p. – 38 – 47.
[20]. E. Fialho, F.S. Moreno, T.P. Ong. Nutrição no pós-genoma: fundamentos e aplicações de ferramentas ômicas. Revista de Nutrição. 2008. Campinas, SP, v.21. n. 6. p. 757 – 766. http://dx.doi.org/10.1590/S1415-52732008000600014.
[21]. T.M.M. Fujji, De R. Medeiros, R. Yamada. Nutrigenômica e nutrigenetica: importantes conceitos para a ciência da nutrição. Artigo de Revisão. Rev. Soc. Alimentação. Nutrição, São Paulo, SP. 2010. v.35, n.1, p.149 – 166, abr.
[22]. C.E. Guerrero-Beltrán, M. Calderón-Oliver, J. Pedraza-Chaverri, Y.I. Chirinho. Protective effect of sulforaphane against oxidative stress: Recent advances. Exp Toxicol Pathol. 2013. v.64. n.5. p.503– 508. DOI: 10.1016/j.etp.2010.11.005
[23]. M.G.V. Gottlieb, I.B.M. Cruz, L.C. Bodanese. Origem da syndrome metabólica: aspectos genético-evolutivos e nutricionais. Artigo de Revisão. Scientia. Médica. 2008. v.18. n.1. p.31 – 38.
[24]. M.C. Krul, C. Humblot, C. Philippe, M. Vermeulen, N.M. Van, R. Havenaar, S. Rabot. Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model. Carcinogenesis. 2002. v.23. p.1009–1016. DOI: 10.1093/carcin/23.6.1009
[25]. T.K. Lam, L. Gallicchio, K. Boyd, M. Shiels, E. Hammond, X. Tao, L. Chen, K.A. Robinson, L.E. Caulfield, J.G. Herman, E.Guallar, and A.J. Alberg. Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review. Cancer Epidemiol Biomarkers Prev. 2009. v.18. n.1. p.184–195. DOI: 10.1158/1055-9965.EPI-08-0710
[26]. C.S.M. Luz, L.S. Sena, W.J.L. Fonseca, G.G, Terto e Sousa, B.S. Abreu, W.L. Fonseca, W.M.F. Rodrigues, L.A. Farias, K.R. dos Santos, SC.S. Júnior. Influências de interações entre gene-ambiente sobre doenças cardiovasculares e nutrição. Nucleus. 2015. v. 12. n. 2. p. 309-320. DOI: http://dx.doi.org/10.3738/1982.2278.1477
[27]. G.S. MACK. Epigenetic cancer therapy makes headway. J Natl Cancer Inst. 2006. v.98. p.1443–4. DOI: 10.1093/jnci/djj447
[28]. L.R. Meyer, A.S. Zweig, A.S Hinrichs, D. Karolchik, R.M. Kuhn, M. Wong, et al. The UCSC Genome Browser database: extensions and updates. Nucleic Acids Res. 2013. v.41. p.D64–9. DOI: 10.1093/nar/gks1048
[29]. M.A Parasramka, W.M. Dashwood, R. Wang, H.H. Saeed, D.E. Williams, E. Ho, and R.H. Dashwood. A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis. Clin Epigenetics. 2012. v.4. p.16-25. DOI: 10.1186/1868-7083-4-16
[30]. H.J.E. Vargas, G.M.P. Camacho, P.D. Ramírez. Efectos de los nutrientes y compuestos bioactivos de los alimentos entejidos y células de cáncer humano: aproximación nutrigenómica. Rev Fac Med. 2013. v.61. n.3. p.293-300. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-00112013000300009&lng=en&nrm=iso&tlng=es
[31]. D.T.H. Verhoeven, H. Verhagen, R.A. Goldbohm, P.A. Van Den Bramdt, G. Van Poppe. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. ChemBiol Interact. 1997. v.103. n.79-129.
[32]. A.J. Wilson, D.S. Byun, N. Popova, L.B. Murray, K. L'Italien, Y. Sowa, D. Arango, A. Velcich, L.H. Augenlicht, and J.M. Mariadason. Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J Biol Chem. 2006. v.281. p.13548–58.
[33]. C. Zhang, Z.Y. Su, T.O. Khor, L. Shu, A.N. Kong.Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. BiochemPharmacol. 2013. v.85. p.1398-404.
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Copyright (c) 2019 Rondon Ramalho, César Augusto Sobrinho, Evair Moisés de Lima Santiago, Marcelo Barbosa Neves, Alessandra de Figueiredo Gonçalves, Eliza Miranda Ramos, Ricardo Dutra Aydos
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Augusto Sobrinho, C., de Lima Santiago, E. M., Barbosa Neves, M., de Figueiredo Gonçalves, A. ., Miranda Ramos, E. ., Dutra Aydos, R. ., & Ramalho, R. (2019). Perspectives of the use of sulforaphane in animal model of colorectal carcinogenesis in Brazil: a review. International Journal for Innovation Education and Research, 7(12), 421-427. https://doi.org/10.31686/ijier.vol7.iss12.2088
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