Effect of physical exercise on colorectal cancer
systematic review
DOI:
https://doi.org/10.31686/ijier.vol9.iss2.2930Keywords:
Colorectal cancer, Physical exercise, Mice and RatsAbstract
Aerobic and resistance physical exercise can activate different molecular pathways due to different intensities, duration, and mechanical loads imposed on the muscles. The activity can result in metabolic adaptations, such as increased mitochondrial mass, oxygen supply, glucose uptake, and antioxidant capacity. The method of this systematic review followed recommendations proposed by the PRISMA Statement. Were included studies that used physical exercise as an intervention in rats and mice with induced colorectal cancer. The Studies' selection was on databases: Bireme, PubMed, Science Direct, Medline, Ibecs, Lilacs, Bdenf, Binacis, Scielo, and bibliographic references selected articles. Animal models researches showed that aerobic and resistance exercise could reduce several risk factors like oxidating stress and the tumor's pro-inflammatory status. That happens due to cytokines' regulation, thereby improve organic's defenses and reduce colon inflammation.
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Copyright (c) 2021 Marcelo Barbosa Neves, Alessandra de Figueiredo Gonçalves, Gabriela Rodrigues Alves; Luiz Carlos Takita; Letícia Silva Fagundes, Ana Keren dos Santos Rocha; Udenilson Nunes da Silva Junior, Julia Fogaça Toniello; Rondon Tosta Ramalho
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Accepted 2021-01-23
Published 2021-02-01
