Application of botulinum toxin in facial paralysis
A review study
DOI:
https://doi.org/10.31686/ijier.vol10.iss7.3833Keywords:
Facial paralysis, Facial nerve, Botulinum toxinAbstract
Botulinum toxin (BT) considered a potent substance with high potential in several treatments, has also been gaining space in dental clinics for the treatment of various pathologies, is safe when used in appropriate doses and contraindications are respected. Before starting BT therapy, it is necessary to communicate the patient about all the potentialities and limitations of treatment. The toxin has become an efficient option for the treatment of facial paralysis (FP), a pathology that causes contraction in the facial muscles, causing temporomandibular dysfunction, damage to the process of eating food and liquids, as well as aesthetic constraints, compromising the patient's quality of life. The objective was to present the application of BT as a therapeutic option in FP. This is a review with qualitative data researched in PubMed, VHL, SciELO and LILACS. Seventy-two studies were found, excluding 27 that were outside the inclusion criteria, and 45 studies were selected. It was found that the first step to its use is to analyze the patient, evaluating the facial resuscitation procedure, defining the possibility of reversal or considerable improvement. Subsequently, it is essential to determine the cause of paralysis, its duration and the functional deficits that the patient presents, after establishing the cause, its indication is evaluated. It is essential that an individualized evaluation is always performed, proposing a realistic therapy, and making the patient aware that it is a temporary treatment. The medical literature also shows a positive effect for the use of BT in the treatment of FP, improving the quality of life, especially the patient's self-esteem.
References
Andalécio MM, Andrade RS, Lima LCS, Carvalho TA, Silva IAPS. The use of botulinum toxin in the treatment of peripheral facial palsy. Research, Society and Development, 2021; 10(9): e8510917935. http://dx.doi.org/10.33448/rsd-v10i9.17935 DOI: https://doi.org/10.33448/rsd-v10i9.17935
Barbosa DBM, Brito AS. A utilização da toxina botulínica tipo A para alcançar a estética facial. Revista Terra & Cultura: Cadernos de Ensino e Pesquisa, 2020; 36(70): 75-86. Available from: http://periodicos.unifil.br/index.php/Revistateste/article/view/1354
Oliveira MD, Valadão IF. A utilização da toxina botulínica em odontologia. Rev Assoc Paul Cir Dent, 2014; 68(3): 244. Available from: http://revodonto.bvsalud.org/pdf/apcd/v68n3/a12v68n3.pdf.
Acosta RT, Kelmer F, Oliveira RCG, Oliveira RCG. Uso da toxina botulínica como meio terapêutico para tratamento de assimetria facial causada por hipertrofia do músculo masséter. Uningá Review, 2015; 21: 24-26. Available from: https://revista.uninga.br/uningareviews/article/view/1618
Ferreira VM, Moreira GL, Morales AFP. A utilização da toxina botulínica no tratamento para paralisia facial. Archives of Health Investigation, 2018; 7. Available from: https://www.archhealthinvestigation.com.br/ArcHI/article/view/3828
Adoni T. Paralisia Facial Periférica. Medicinanet, 2008. Available from: https://www.medicinanet.com.br/conteudos/revisoes/1191/paralisia_facial_periferica.htm#:~:text=A%20causa%20mais%20comum%20de,por%20volta%20dos%2040%20anos
Valença MM, Valença LPAA, Lima MCM. Paralisia facial periférica idiopática de Bell: a propósito de 180 pacientes. Arquivos de Neuro-Psiquiatria, 2001; 59(3B): 733-739. https://doi.org/10.1590/S0004-282X2001000500016 DOI: https://doi.org/10.1590/S0004-282X2001000500016
Carvalho VAS, Silva TS, Melo MAMO, et al. Paralisia facial unilateral: aspectos clínicos e principais tratamentos. Braz J Hea Rev, Curitiba, 2020; 3(2): 1761-1765. https://doi.org/10.34119/bjhrv3n2-036 DOI: https://doi.org/10.34119/bjhrv3n2-036
Wenceslau LGC, Sassi FC, Magnani DM, Andrade CRF. Paralisia facial periférica: atividade muscular em diferentes momentos da doença. CoDAS. 2016; 28: 03-09. https://doi.org/10.1590/2317-1782/20162015044. DOI: https://doi.org/10.1590/2317-1782/20162015044
Calais LL, Gomez MVSG, Bento RF, Comerlatti LR. Avaliação funcional da mímica na paralisia facial central por acidente cerebrovascular. Pró-Fono Revista de Atualização Científica, 2005; 17(2): 213-222. https://doi.org/10.1590/S0104-56872005000200010 DOI: https://doi.org/10.1590/S0104-56872005000200010
Tacon KCB, Pereira ECR, Rodrigues PCR, et al. Paralisia facial periférica: perfil dos pacientes atendidos em uma clínica escola. Movimenta, 2019; 12(2): 220-228. Available from: https://www.revista.ueg.br/index.php/movimenta/article/view/8004
Garanhani MR, Cardoso JR, Capelli AMG, Ribeiro MC. Fisioterapia na paralisia facial periférica: estudo retrospectivo. Rev Bras Otorrinolaringol, 2007; 73: 112-115. https://doi.org/10.1590/S0034-72992007000100018 DOI: https://doi.org/10.1590/S0034-72992007000100018
Salles AG. Avaliação do efeito da toxina botulínica no lado são em pacientes com paralisia facial de longa duração. Tese de Doutorado em Ciência, Universidade de São Paulo, São Paulo. 2006. Available from: https://teses.usp.br/teses/disponiveis/5/5158/tde-27082009-152705/pt-br.php
Lang A. History and uses of BOTOX (botulinum toxin type A). Lippincotts Case Manag, 2004; 9(2): 109-12. https://doi.org/10.1097/00129234-200403000-00011. DOI: https://doi.org/10.1097/00129234-200403000-00011
Setler PE. Therapeutic use of botulinum toxins: background and history. Clin J Pain; 2002; 18(6 Suppl): S119-24. https://doi.org/10.1097/00002508-200211001-00002 DOI: https://doi.org/10.1097/00002508-200211001-00002
Yablon S. Toxin neutralizing antibody formation with botulinum toxin type A (BoNTA) treatment in neuromuscular disorders. Neurology, 2005; 64: 1153. DOI: https://doi.org/10.1055/s-2005-919410
Poulain B, Popoff MR, Molgó J. How do the botulism neurotoxins block neurotransmitter release: from botulism to the molecular mechanism of action. The Botulinum J. 2008; 1: 14-87. https://doi.org/10.1504/TBJ.2008.018951 DOI: https://doi.org/10.1504/TBJ.2008.018951
Colhado OCG, Boeing M, Ortega LB. Toxina botulínica no tratamento da dor. Revista Brasileira de Anestesiologia, 2009; 59(3): 366-381. https://doi.org/10.1590/S0034-70942009000300013 DOI: https://doi.org/10.1590/S0034-70942009000300013
Malizio CJ, Goodnough MC, Johnson EA. Purification of Clostridium botulinum type A neurotoxin. Methods Mol Biol, 2000; 145: 27-39. https://doi.org/10.1385/1-59259-052-7:27 DOI: https://doi.org/10.1385/1-59259-052-7:27
Aoki KR. A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice. Toxicon, 2001; 39(12): 1815-20. https://doi.org/10.1016/s0041-0101(01)00101-5 DOI: https://doi.org/10.1016/S0041-0101(01)00101-5
Aoki KR. Pharmacology and immunology of botulinum toxin serotypes. J Neurol, 2001; 248(Suppl 1): 3-10. https://doi.org/10.1007/pl00007816 DOI: https://doi.org/10.1007/PL00007816
Wohlfarth K, Kampe K, Bigalke H. Pharmacokinetic properties of different formulations of botulinum neurotoxin type A. Mov Disord 2004; 19: 65-67. https://doi.org/10.1002/mds.20012 DOI: https://doi.org/10.1002/mds.20012
Truong DD, Stenner A, Reichel G. Current clinical applications of botulinum toxin. Curr Pharm Des. 2009; 15(31): 3671-3680. https://doi.org/10.2174/138161209789271843. DOI: https://doi.org/10.2174/138161209789271843
Ênia JRN, Fernandes JGA, Nascimento F, et al. Toxina botulínica no tratamento da paralisia facial: um tratamento reabilitador minimamente invasivo. Research, Society and Development, 2021; 10(5): e40510515204. http://dx.doi.org/10.33448/rsd-v10i5.15204 DOI: https://doi.org/10.33448/rsd-v10i5.15204
Klein AW. The therapeutic potential of botulinum toxin. Dermatol Surg, 2004; 30(3): 452-455. https://doi.org/10.1111/j.1524-4725.2004.30118.x. DOI: https://doi.org/10.1111/j.1524-4725.2004.30118.x
Dressler D, Saberi FA, Barbosa ER. Botulinum toxin: mechanisms of action. Arquivos de Neuro-Psiquiatria, 2005; 63: 180-185. https://doi.org/10.1590/S0004-282X2005000100035. DOI: https://doi.org/10.1590/S0004-282X2005000100035
Domingos MM. O uso da toxina botulínica em doentes com hipercinesia muscular facial contralateral à paralisia facial. Tese de Doutorado em Ciência, Universidade de São Paulo, São Paulo. 2006. Available from: https://www.teses.usp.br/teses/disponiveis/5/5143/tde-17082006-104941/pt-br.php
Cooper L, Lui M, Nduka C. Botulinum toxin treatment for facial palsy: A systematic review. J Plast Reconstr Aesthet Surg, 2017; 70(6): 833-841. https://doi.org/10.1016/j.bjps.2017.01.009 DOI: https://doi.org/10.1016/j.bjps.2017.01.009
Dall’Magro AK, Santo R, Dall’Magro E, et al. Aplicações da toxina botulínica em odontologia. Rev Salusvita, 2015; 34(2): 371-382. Available from: https://secure.unisagrado.edu.br/static/biblioteca/salusvita/salusvita_v34_n2_2015_art_14.pdf
Marciano AM, Aguiar U, Vieira PGM, Magalhães SR. Toxina botulínica e sua aplicação na odontologia. Rev Iniciaç Cient Universidade Vale Rio Verde, 2014; 4: 65-75. Available from: http://periodicos.unincor.br/index.php/iniciacaocientifica/article/view/1554
Serrera-Figallo M-A, Ruiz-de-León-Hernández G, Torres-Lagares D, et al. Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins (Basel), 2020; 12(2): 112. https://doi.org/10.3390/toxins12020112 DOI: https://doi.org/10.3390/toxins12020112
Santos CF, Stresser KCA, Oliveira AMM, et al. Aplicação de toxina botulínica tipo A em paciente com paralisia facial periférica de Bell: relato de caso. RSBO, 2020; 17(2): 221-225. https://doi.org/10.21726/rsbo.v17i2.51 DOI: https://doi.org/10.21726/rsbo.v17i2.51
Sheean G. Botulinum toxin for the treatment of musculoskeletal pain and spasm. Curr Pain Headache Rep, 2002; 6(6): 460-469. https://doi.org/10.1007/s11916-002-0065-y DOI: https://doi.org/10.1007/s11916-002-0065-y
Guerra Neto PGS. Toxina botulínica tipo A: ações farmacológicas e riscos do uso nos procedimentos estéticos faciais. 2016. 44 f. Monografia (Especialização em Biomedicina Estética) - Instituto Nacional de Ensino Superior e Pesquisa e Centro de Capacitação Educacional, Recife, 2016. Available from: https://www.ccecursos.com.br/img/resumos/2-toxina-botul-nica-tipo-a-a--es-farmacol-gicas-e-riscos-do-uso-nos-procedimentos-est-ticos-faciais.pdf
Vicente JM. Paralisia de Bell, do diagnóstico ao tratamento: revisão de literatura. Artigo do Centro Universitário São Lucas. Porto Velho-RO 2019. Available from: http://repositorio.saolucas.edu.br:8080/xmlui/bitstream/handle/123456789/3196/Jalisson%20Mendes%20Vicente%20-%20Paralisia%20de%20Bell%2C%20do%20diagn%C3%B3stico%20ao%20tratamento%20revis%C3%A3o%20de%20literatura.pdf?sequence=1&isAllowed=y
Lew MF. Review of the FDA-approved uses of botulinum toxins, including data suggesting efficacy in pain reduction. Clin J Pain, 2002; 18(6suppl): s142-146. https://doi.org/10.1097/00002508-200211001-00005 DOI: https://doi.org/10.1097/00002508-200211001-00005
Alves FC, Souza FB. A utilização da Toxina Botulínica na odontologia. 2016. Dissertação (Graduação em Odontologia) – Curso de Odontologia do UniSL, Centro Universitário São Lucas - UNISL, Porto Velho, 2016. Disponível em: http://repositorio.saolucas.edu.br:8080/xmlui/handle/123456789/1673.
Lima PN, Gusmão RM, Siqueira NCG, Varejão LC. Toxina botulínica como alternativa no tratamento da paralisia facial de Bell: revisão de literatura. BJD, 2020; 6(12): 95667-95681. https://doi.org/10.34117/bjdv6n12-161 DOI: https://doi.org/10.34117/bjdv6n12-161
Ikeda EMG, Oliveira RCG, Oliveira RCG, Freitas KMS. Efeitos da toxina botulínica no tratamento odontológico. Revista Uningá, 2019; 56(S5), 153-162. Available from: https://revista.uninga.br/uninga/article/view/318
Shinn JR, Nwabueze NN, Liping Du L, et al. Treatment patterns and outcomes in botulinum therapy for patients with facial synkinesis. JAMA Facial Plast Surg, 2019; 21(3): 244-251. https://doi.org/10.1001/jamafacial.2018.1962 DOI: https://doi.org/10.1001/jamafacial.2018.1962
do Nascimento Remigio AF, Salles AG, de Faria JCM, Ferreira MC. Comparison of the efficacy of onabotulinumtoxin A and abobotulinumtoxin A at the 1: 3 conversion ratio for the treatment of asymmetry after long-term facial paralysis. Plast Reconstr Surg, 2015; 135: 239-249. https://doi.org/10.1097/PRS.0000000000000800. DOI: https://doi.org/10.1097/PRS.0000000000000800
Mandrini S, Comelli M, Dall'angelo A, et al. Long-term facial improvement after repeated BoNT-A injections and mirror biofeedback exercises for chronic facial synkinesis: a case-series study. Eur J Phys Rehabil Med, 2016; 52(6): 810-818. Available from: https://pubmed.ncbi.nlm.nih.gov/27164539/
Cunha SCN. Paralisia facial periférica diagnóstico e tratamento. Mestrado (Mestrado em Medicina) - Faculdade Ciências da Saúde da Universidade da Beira Interior, Covilhã, 2018. Available from: https://ubibliorum.ubi.pt/bitstream/10400.6/8359/1/6069_12733.pdf
Maio M, Soares MFD. Toxina botulínica em paralisia facial: um tratamento minimamente invasivo para redução da hipercinesia muscular da região perioral contralateral. Arquivos Internacionais de Otorrinolaringologia, 2006; 11: 38-35. Available from: http://arquivosdeorl.org.br/conteudo/pdfForl/401.pdf
Ferreira VM, Moreira GL, Morales AFP. A utilização da toxina botulínica no tratamento para paralisia facial. Archives of Health Investigation, 20019; 7: 1. Available from: https://www.archhealthinvestigation.com.br/ArcHI/article/view/3828.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Beatriz Brumato Macedo, Rogério Rodrigo Ramos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyrights for articles published in IJIER journals are retained by the authors, with first publication rights granted to the journal. The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author for more visit Copyright & License.
How to Cite
Accepted 2022-06-24
Published 2022-07-01
Most read articles by the same author(s)
- Bianca Garcia Botelho de Andrade, Jaqueline Fernandes, Amanda Fedozi Tonon, Eleusa Gomes Muniz Ribeiro, Rogério Rodrigo Ramos, José Martins Pinto Neto, André Wilian Lozano, Incidence of syphilis in pregnant women in the countryside of são paulo from 2018 to 2020 , International Journal for Innovation Education and Research: Vol. 10 No. 4 (2022): International Journal for Innovation Education and Research
- Martha Naves de Oliveira, Dora Inés Kozusny-Andreani, Rogério Rodrigo Ramos, Hospital effluent care with ozone for inactivation of potentially pathogenic bacteria , International Journal for Innovation Education and Research: Vol. 10 No. 5 (2022): International Journal for Innovation Education and Research
- João Pedro Fernandes Egídio de Toledo, Leonardo Arendt Ferreira, Leonardo Augusto de Souza, Flávia Roberta Posterli Cavalcante, Rafaela Cristina Soares Rebucci, Marcella Thalia Teixeira da Silva, Márcio Miranda Santos, Rone Roberto Campana dos Santos, Hevander Gabriel Pereira de Souza, Igor Pereira Peixoto Guimaraes, Rogério Rodrigo Ramos, Neurological changes post-covid-19 infection , International Journal for Innovation Education and Research: Vol. 10 No. 9 (2022): International Journal for Innovation Education and Research
- Anayque Taihara de Oliveira Ribeiro, Fabiano da Silva Feitosa, Igor Donizete Fernandes, Haiany Cruz dos Santos, Emannuelly Mara de Oliveira, Mayani Alves Almeida, Maria Eduarda de Oliveira Borges, Shelton Fernando Neves Pedroso, Mariana Dyna Pedrão, José Theodoro de Araújo Oliveira, Jussara Britto Batista Gonçalves, Elena Carla Batista Mendes, Rogério Rodrigo Ramos, Autonomy In the Choice of Childbirth in The Primiparous , International Journal for Innovation Education and Research: Vol. 10 No. 9 (2022): International Journal for Innovation Education and Research