Action of cyanogenic substances and magnetic field in the reduction of neoplasms

An integrative literature review

Authors

  • Thais da Cruz Penha Jabrayan
  • Rondon Tosta Ramalho Universidade Federal de Mato Grosso do Sul/UFMS
  • Valdir Aragão Nascimento Centro Universitário Anhanguera de Campo Grande MS https://orcid.org/0000-0002-1125-5100
  • Melissa da Cruz Penha Friozi Federal University of Mato Grosso do Sul
  • Joaquim Borges de Menezes Neto Federal University of Mato Grosso do Sul
  • Priscila Gonçalves Soares dos Santos Federal University of Mato Grosso do Sul
  • Igor Domingos de Souza
  • Hugo Vieira Ramos Federal University of Mato Grosso do Sul
  • Iara Barbosa Ramos

DOI:

https://doi.org/10.31686/ijier.vol10.iss7.3738

Keywords:

Neoplasm, Magnetic Field Therapy, Amygdaline

Abstract

Cancer treatment has been constantly improved to cause the least possible harm to the patient. New therapies are being researched, many of them having as object of scientific-academic and pharmacological research the use of cyanogenic plants and their antitumor chemical compounds that can bring benefits to human health, having the potential to be associated with the magnetic Field and thus achieve a better benefit and with reduced adverse effects in cancer treatment. This study aimed to review the effect of cyanogenic substances and magnetic Field on tumor evolution in the literature. The integrative review of the literature was carried out in the databases EMBASE, PUBMED, LILACS, VHL, SCOPUS and MEDLINE. A final sample of 14 scientific articles, published from 2011 to 2020, was obtained, highlighting that cyanogenic substances and the magnetic Field can help reduce tumors. The most common studies were on the magnetic Field, and the studies were carried out mainly in vitro, with a frequency of 50 Hz that stood out from the others. Among the cyanogenic substances, the most prevalent was tonsillin, with the most used dosage of 10mg / ml. It was possible to conclude that both the magnetic Field and cyanogenic substances can reduce tumors.

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Author Biographies

  • Thais da Cruz Penha Jabrayan
    Professor at the Anhanguera Pitágoras Unopar University Center in Campo Grande
  • Rondon Tosta Ramalho, Universidade Federal de Mato Grosso do Sul/UFMS

    Professor at Federal University of Mato Grosso do Sul

  • Melissa da Cruz Penha Friozi, Federal University of Mato Grosso do Sul

    Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro-Oeste/PPGSD

  • Joaquim Borges de Menezes Neto, Federal University of Mato Grosso do Sul

    Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro-Oeste/PPGSD

  • Priscila Gonçalves Soares dos Santos, Federal University of Mato Grosso do Sul

    Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro-Oeste/PPGSD

  • Igor Domingos de Souza
    Anhanguera Pitágoras Unopar University Center in Campo Grande
  • Iara Barbosa Ramos
    Anhanguera Pitágoras Unopar University Center in Campo Grande

References

ALMEIDA, V. L.; REINA A.L.L. C; MONTANARI, C.A;; DONNICI, C. L Cancer and specific cyclocellular antineoplastic agents and non-specific cyclo-cellular that interact with DNA: An introduction. Quim Nova, v. 28, n. 1, p.118-129, 2005. DOI: https://doi.org/10.1590/S0100-40422005000100021

AMIRI, M; BASIRI, M; ESKANDARY, H; AKBARNEJAD, Z; ESMAEELI, M; MASOUMI-ARDAKANI, Y; AHMADI-ZEIDABADI, M Cytotoxicity of carbo ́lation on human glioblastoma cells is reduced by the concomitant exposure to an extremely low-frequency electromagnetic Field. Electromagnet biology and Medicine, v. 37, n. 3, p. 138-145, 2018. DOI: https://doi.org/10.1080/15368378.2018.1477052

BALICK, M.; COX, P. Plants, peoples and culture: the science of ethno botany. 2nded. New York: Scientific American Library. 1997.

BARBOSA, M. P.; PETTERINI, F.C.; FERREIRA, R. T. Evaluation of the Impact of the expansion policy of federal universities on municipal economies. In: National Association of Graduate Centers in Economics. [S.l.]. 2015. Available in: HTTPS://www.anpec.org.br/encontro/2015/submissao/files_I/i12-6599011d2e3082ef34b038002f88e41c.pdf >. Accessed Aug. 8. 2021.

BECKER, R. O. Electromagnetic forces and life process. Technology Review (MIT) 75:32-38, 1972.

BLAHETA, R. A. NELSON, K; HAFERKAMPA, X; JUENGEL, E. Amygdaline, quackery or cure? Phytomedicine, v. 23, Issue 4, 2016, Pages 367-376, ISSN 0944-7113, HTTPS://doi.org/10.1016/j.phymed. 2016.02.004. DOI: https://doi.org/10.1016/j.phymed.2016.02.004

BRAZIL. Ministry of Health. National Cancer Institute. Policies and actions for cancer prevention in Brazil: food, nutrition and physical activity. / National Cancer Institute. – Rio de Janeiro: INCA, 2009. Available: http://bvsms.saude.gov.br/bvs/publicacoes/sumario_executivo_politicas_acoes_ prevencao_cancer.pdf

BRAY, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, Hoboken, v. 68, n. 6, p. 394-424, Nov. 2018. DOI: https://doi.org/10.3322/caac.21492

BURROWS, G. E. Cyanidintoxicationin sheep: Therapeutics. Veterinary Human Toxicology, v. 23, p. 22-28. 1981.

BRAZIL. Ministry of Health. RENISUS - National List of Medicinal Plants of Interest to SUS. Plant speris. DAF/SCTIE/MS-RENISUS-2009. Available in: http://portal.saude.gov.br/portal/arquivos/pdf/RENISUS. Pdf acesso: on 20 Jul. 2021

BRAZIL. Ministry of Health. Methodological guidelines: Preparation of systematic review and meta-analysis of comparative observational studies of risk and prognosis. 1st edition. Brasilia, 2014.

CAMARA, A.C. L.; DALCIN, L.; SOTO-BLANCO, B, Benito Pathogenesis, clinical signs and epidemiology of poisoning by cyanogenic plants in northeastern Brazil. Semina: Agrarian Sciences [online]. 2014, 35(4), 1961-1971 Available in: HTTPS://www.redalyc.org/articulo. oa?id=445744142049 DOI: https://doi.org/10.5433/1679-0359.2014v35n4p1961

CEDOC. Mendeley Manual/Tutorial. State University of Campinas Institute of Economics Prepared by IE/CEDOC Library, 2017. Available from: HTTPS://www.eco.unicamp.br/biblioteca/images/arquivos/pdf/Tutorial_Mendeley_ Pietra.pdf Accessed: 22 Aug. 2021.

CEREDA, M.P.; MATTOS, M.C. Y. Linamarin: the toxic compound of cassava. Journal of Venomous Animals and Toxins, v. 2, p. 6-12. 1996. DOI: https://doi.org/10.1590/S0104-79301996000100002

CHENG, Y; MUROSKI, R.A.; PETIT, D.C.M. C; MANSELL, R; VEMULKAR, T; MORSHED, R.A.; HAN, Y; BALYASNIKOVA, I.V; HORBINSKI, C.M; HUANG, X; ZHANG, L; COWBURN, R.P.; LESNIAL, M.S Rotating magnetic Field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma. Journal of controlled release: official journal of the controlled Release Society. V.223, p. 75-84, 2016. DOI: https://doi.org/10.1016/j.jconrel.2015.12.028

COELHO-FERREIRA, M. R. Identification and valorization of medicinal plants of a fishing community of the coast of Pará (Brazilian Amazon). 2000. 269 p. Thesis (Doctorate in Botany) - Federal University of Pará, Museum Paraense Emílio Goeldi/EMBRAPA, Belem.

COSTA, R. J. O. Phytochemical profile of ethanol extract from jatropha mollissima (Pohl) Baill leaves. And evaluation of its toxicological, antitumor and antibacterial activity. 2018. 82f. Thesis (Master's degree in Pharmaceutical Sciences) - Area of concentration: Natural Products and their bioactive compounds. Federal University of Pernambuco, Recife, 2018.

CROCETTI, S; BEYER, C; SCHADE, G; EGLI, M; FRÖHLICH, J; FRANCO-OBREGÓN, A. Low intensity and frequency pulsed electromagnetic Fields selective lyimpair breast cancer cell viability. Mr. PLosOne. V. 8, n.9, DOI: https://doi.org/10.1371/journal.pone.0072944

DAVIS, S.; MIRICK, D. K.; STEVENS,R. G. Night shift work, light at night, and risk of breast cancer. Journal of the National Cancer Institute, v. 93, n. 20, October 17, 2001. Available from: http://citeseerx.ist.psu.edu/viewdoc/download; jsessionid=F8BEBD09392A4A70 599367FEBD79085E? Doi=10.1.1.1005.5902&rep=rep1&type=pdf Access: 13 Oct. 2021.

JJ DEEKS, JPT Higgins, ALTMAN DG. CHAPTER 9: ANALYSING DATA AND UNDERTAKING META‐ ANALYSES. IN: HIGGINS JPT, GREEN S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐ handbook.org.

EL-BIALY, N; RAGEH, M.M. Extremely low-frequency magnetic Field enhances the therapeutic efficacy of low-dose cisplatin in the treatment of Ehrlich carcinoma. Biomed research international, v.2013, 2013. DOI: https://doi.org/10.1155/2013/189352

EL-MASRY, T; AL-SHAALAN, N; TOUSSON, E; BUABEID, M; AL-GHADEER, A. Potential therapy of vitamin B17 against Ehrlich solid tumor induced changes in Interferon gamma, Nuclear factor kappa b, DNS fragmentation, p53, Bcl2, surviving, VEGF and TNF- α Expressions in mice. Pakistan Journal of Pharmaceutical Sciences, v. 33, n.1, p. 393-401, 2020.

FAN, Z; HU, P; XIANG, L; LIU, Y; HE, R; LU, T A static magnetic Field inhibits the migration in telomerase function of mouse breast cancer cells. Biomed research international. V. 2020, p.9, 2020. DOI: https://doi.org/10.1155/2020/7472618

FERLAY, J; SOERJOMATARAM, I; ERVIK, M; MATHERS, C; REBELO M; PARKIN, D.M; Cancern. Incidence and Mortality Worldwide: IARC 2013.

DIKSHIT, R; ESER, S; FORMAN, D; BRAY, F. Cancer Base, v. 1, n. 11,

FURTADO, J.L. B; BEZERRA, C.W. B; MARQUES, E.P; MARQUES, A.L.B. Cyanide in tiquiras: risks and analytical methodology. Science. Tecnol. Aliment, v.27, n.4, p. 694-700, 2007. DOI: https://doi.org/10.1590/S0101-20612007000400004

GALVÃO, C.M.; SAWADA, NO; TREVIZAN, M.A. Systematic review: a resource that provides the incorporation of evidence in nursing practice. Magazine. Latin American Nursing. V.12, n.3, p.549-56, 2004 DOI: https://doi.org/10.1590/S0104-11692004000300014

GARCIA-ESCUDERO, V; GARGINI, R; IZQUIERDO, M. Glioma regression in vitro and in vivo by a suicide combined treatment. Molecular cancer research: MCR, v.6, n. 3, p, 407-417, 2008. DOI: https://doi.org/10.1158/1541-7786.MCR-07-0243

GAROFOLO, A.; AVESANI, C.M.; CAMARGO, K. G.; BARROS, M. E; JUSTINO SILVA, R.R.; TADDEI, J.A.A.C.; SIGULEM. D.M.Diet and cancer: an epidemiological approach. Rev. Nutr., Campinas, v. 17, n. 4, p. 491-505, 2004. DOI: https://doi.org/10.1590/S1415-52732004000400009

GIRALD, W; COLLIN, A; IZQUIERDO, M. Toxicity and delivery methods for the linamarase/linamarin/glucose oxidase system, when used against human glioma tumors implanted in the brain of nude rats. Cancer Letters, v. 313, n.1, p. 99-107, 2011. DOI: https://doi.org/10.1016/j.canlet.2011.08.029

GELLRICH, D.; SCHMIDTMAYER, U.; ECKRICH, J.; HAGEMANN,J.; BECKER,S.; STRIETH,S. Modulation of Exposure to Static Magnetic Field Affects Targeted Therapy of Solid Tumors In Vivo. Anticancer Res., Aug; v. 38, DOI: https://doi.org/10.21873/anticanres.12759

N. 8, p. 4549-4555, 2018. Available HTTPS://pubmed. Ncbi. nlm.nih.gov/30061221/ Access: 12 Oct. 2021.

GYE, M.C; PARK, C.J. Effect of electromagnetic Field exposure on the reproductive system. Clin Exp Reprodmed; v.39, n.1, p.1-9, 2012. DOI: https://doi.org/10.5653/cerm.2012.39.1.1

HAYT, W.H; BUCK, J.A. Electromagnetism. McGraHill Publishing House, São Paulo - SP, 2011.

HE, X-Y; W, L-J; WANG, W-X; XIE, P-J, CHEN, Y-H, WANG, F.The ethno pharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review. Journal of ethno pharmacology, v. 254, 2020. HIGGINS JPT, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Statistics in medicine 2002; 21:1539‐59. DOI: https://doi.org/10.1002/sim.1186

HIGGINS JPT, THOMPSON SG, JJ DEEKS, ALTMAN DG. Measuring inconsistency in meta‐analyses. BMJ 2003; 327:557‐60 DOI: https://doi.org/10.1136/bmj.327.7414.557

HUGHES, S; MCBAIN, S; DOBSON, J; HAJ, A.J.E. Selective activation of mechanic sensitive ion channels using magnetic particles J R Soc Interface., v.5, n. 25, p. 855–863, 2008. DOI: https://doi.org/10.1098/rsif.2007.1274

NATIONAL CANCER INSTITUTE JOSÉ ALENCAR GOMES DA SILVA / INCA. Estimate 2020: Cancer statistics / National Cancer Institute José Alencar Gomes da Silva. – Rio de Janeiro: INCA, 2021. Available from: HTTPS://www.inca.gov.br/numeros-de-cancer Access: 12 Oct. 2021

INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA. Coordination of Prevention and Surveillance. Estimative2014: Incidence of Cancer in Brazil/National Cancer Institute José Alencar Gomesda Silva, Coordination of Prevention and Surveillance. Rio de Janeiro: INCA, 2014. Available in: http://www.saude.sp.gov.br/resources/ses/perfil/gestor/homepage/outros- highlights /estimativa-de-incidencia-de-cancer- 2014/estimativa_cancer_24042014.pdf

NATIONAL CANCER INSTITUTE JOSÉ ALENCAR GOMES DASILVA/INCA. Estimate 2020: incidence of cancer in Brazil / Instituto Nacional de Câncer José Alencar Gomes da Silva. – Rio de Janeiro: INCA, 2019. Available in: HTTPS://www.inca.gov.br/sites/ufu. sti.inca.local/files//media/document//estimativa

-2020-incidencia-de-cancer-no-brasil. PDFACCESS: 13 Jul. 2021.

KELLERMEYER, L. et al. "Covidence and Rayyan." Journal of the Medical Library Association: JMLA v. 106.n.4, p. 580-583, 2018 DOI: https://doi.org/10.5195/jmla.2018.513

KOH, E. K; RYU, B-K; JEONG, D-Y; BANG, I-S; NAM, M.H.; CHAE, K-S. A 60-Hz sinusoidal magnetic Field induces apoptosis of prostate cancer cells through reactive oxygen species. Int J Radiatbiol, v.84, n. 11, p.945-55, 2008. DOI: https://doi.org/10.1080/09553000802460206

KOZISSNIK, B; BOHORQUEZ, A.C; DOBSON, J; RINALDI, C. Magnetic fluid hyperthermia: Advances, challenges, and opportunity. International Journal of Hyperthermia, 2013. DOI: https://doi.org/10.3109/02656736.2013.837200

KRANJC, S; KRANJC, M; SCANCAR, J; JELENC, J; SERSA, G; MIKLAVCIC, D. Electro chemotherapy by pulsed electromagnetic Field treatment (PEMF) in mouse melanoma B16F10 in vivo. Radiology and oncology, v. 50, n. 1; p. 39-48, 2016. DOI: https://doi.org/10.1515/raon-2016-0014

LAI, H.; SINGH, N. P. Melatonin and N-tert-butyl-α-phenylnitrone block 60-Hz magnetic Field-induced DNA single and Double strand breaks in rat brain cells. JOURNAL OF PINEAL RESEARCH, v. 22, issue 3. 30 January 2007 HTTPS://doi.org/10.1111/j.1600-079X.1997.tb00317.x DOI: https://doi.org/10.1111/j.1600-079X.1997.tb00317.x

LAURELL, A.C. La salud-enfermedadcomoprocesosocial . Revista Latino Americana de Salud, Mexico, 2, 1982, p. 7-25. Trad. E. D. Nunes. Available at: HTTPS://unasus2. Moodle. UFSC. BR/pluginfile. Php/6126/mod_resource/content/1/Conteudo_on-line_2403/un01/pdf/ARTIGO_A_SAUDE-DOENCA. PDFACCESS: 4 Jun. 2021.

LECHTER, G. S. Electromagnetic radiation. PC Mag Bras. 44-54, dec, 1991.

LICZBINSKI, P; BUKOWSKA, B. Immunopharmacology and immunotoxicology, v. 40, n. 3, p. 212-218, 2018. DOI: https://doi.org/10.1080/08923973.2018.1441301

MAKAREVIC, J; RUTZ, J; JUENGEL, E; KAULFUSS, S; REITER, M; TSAUR, I; BARTSCH, G; HAFERKAMP, A; BLAHETA, R.A.Plos One, v.9, n. 8, 2014. DOI: https://doi.org/10.1371/journal.pone.0105590

MAKAREVIC, J; TSAUR, I; JUENGEL, E; BORGMANN, H; NELSON, K; THOMAS, C; BARTSCH, G; HAFERKAMP, A; BLAHETA, R.A. Amygdalin delays cells cycle progression and blocks growth of prostate cancer cell in vitro. Life sciences, v.147, p. 137-142, 2016. DOI: https://doi.org/10.1016/j.lfs.2016.01.039

MANI, J; NEUSCHÄFER, J; RESCH, C; RUTZ, J; MAXEINER, S; ROOS, F; CHUN, F. K-H; JUENGEL, E; BLAHETA, R.A.Nutrition and cancer, v. 72, n. 3, p. 528-537, 2020. DOI: https://doi.org/10.1080/01635581.2019.1637442

MARCILIO, I; HABERMANN, M; GOUVEIA, N. Magnetic Field of extremely low frequency and health effects: review of the literature e. Revista Brasileira de Epidemiologia, v. 12, n. 2, p. 105-123, 2009. DOI: https://doi.org/10.1590/S1415-790X2009000200002

MARINO, A.A; MORRIS, D.M 1999. Chronic electromagnetic stressors in the environment: a risk factor in human cancer. Shreveport, 1999. Available<http://www.ortho.lsume.edu/faculty? Marino/Papers/Cite67 Access in 2021.

MOSAYYEBI, B; IMANI, M; MOHAMMADI, L; AKBARZADEH, A; ZARGHAMI, N; EDALATI, M; ALIZADEH, E; RAHMATI, M. An update on the toxicity of cyanogenic glycosides bioactive compounds: Possible Clinical Application in targeted cancer therapy. Materials Chemistry and Physics, v.246, 2020. DOI: https://doi.org/10.1016/j.matchemphys.2020.122841

MUKHERJEE, S. The Emperor of all males: a biography of cancer. São Paulo: Companhia das Letras, 2012.

MURAGAKI, Y; ISEKI, H.; MARUYAMA, T.; KAWAMATA, T.; YAMANE, F.; NAKAMURA, R.; KUBO, O.; TAKAKURA, K.; HORI, T. Usefulness of intraoperative magnetic resonance imaging for glioma surgery. Acta Neurochir Suppl. V. 98, p. 67-75, 2006. Doi: 10.1007/978-3-211-33303-7_10. PMID: 17009703. DOI: https://doi.org/10.1007/978-3-211-33303-7_10

MUSSOI, F. L. R. Fundamentals of Electromagnetism. CEFET Santa Catarina, Florianópolis, 2005.

OUZZANI, M.; HAMMADY, H.; FEDOROWICZ, Z.; ELMAGARMID, A. et al. Rayyan—a web and mobile app for systematic reviews. SystVer. V. 5, 210 2016. HTTPS://doi.org/10.1186/s13643-016-0384-4. DOI: https://doi.org/10.1186/s13643-016-0384-4

PAGE, Matthew J. ET al. The PRISMA 2020 statement: in the updated guideline for reporting systematic reviews. Bmj, v. 372, 2021.

PIRES, C.A. A; FAYAL, A.P.; CAVALCANTE, R.H.; FAYAL, S.P.; LOPES, N.S. FAYAL, F.P; SANTOS, M.A.L. Skin cancer: characterization of the profile and evaluation of the Sun protection of patients treated at a university service. Health Biol Sci, v.6, n.1, p.54-59, 2018. DOI: https://doi.org/10.12662/2317-3076jhbs.v6i1.1433.p54-59.2018

QADIR, M; FATIMA, K. Review on Pharmacological Activity of Amygdalin. Arch Can Res, Pakistan, v.5, n.4, p.160, 2017. DOI: https://doi.org/10.21767/2254-6081.100160

RAMALHO, R.T;; AYDOS, R.D;; CEREDA, M.P;; Evaluation of acetone cyanohydrins effect in "in vitro" inactivation of the Ehrlich ascites tumor cells. Brazilian Surgical Acta, v. 25; n.1; 2010. DOI: https://doi.org/10.1590/S0102-86502010000100022

RAMALHO, R.T; AYDOS, R.D;; SCHETTERT, I; ASSIS, P.V; CASSINO, P.C. Sulfane sulfur deficiency in malignant cells, increasing the inhibiting action of acetone cyanohydrin in tumor growth, Acta Cirúrgica Brasileira, v.28; n.10; 2013. DOI: https://doi.org/10.1590/S0102-86502013001000007

RAMALHO, R.T; AYDOS, R.D;; SCHETTERT, I; CASSINO, P.C. Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy. Brazilian Surgical Acta, v. 29; n. 2; 2014 DOI: https://doi.org/10.1590/S0102-8650201400140008

RIGHI, L. A. Electromagnetism for Electrical Engineering. Publisher Federal University of Santa Maria - UFSM, Santa Maria - RS, 2013.

RUFINO, M. N. et al. Choline Symptomatology, Biochemical and Tissue Changes Observed After Oral Administration of Acetone Cyanidrin in the Murine Model. 2014. 59f. Thesis (Master's degree inbiotecnology applied to health) Graduate Program in Biotechnology, Catholic University Don Bosco Catholic, Campo Grande, MS, 2014.

SALIEV, T; BEGIMBETOVA, D; MASOUD, AR; MATKATIMOV, B.

Biologicaleffectsofnon-ionizingelectomagneticfields: Twosidesofacoin.

Progress in biophysics and molecular biology. V. 141, p. 25-36, 2019. DOI: https://doi.org/10.1016/j.pbiomolbio.2018.07.009

SHI, J; CHEN, Q; XU, M; XIA, Q; ZHENG, T; TENG, J; LI M; ANA, L. Cancer Medicine. V. 8, n. 6, p. 3004-3011, 2019. DOI: https://doi.org/10.1002/cam4.2197

SHINKAI, M; UEDA, K; OHTSU, S; HONDA, H; KOHRI, K; KOBAYASHI, T. Effect of functional magnetic particles on radiofrequency capacitive heating: an in vivo Study. Jpn J Cancer Res. 2002; v.93; p.103-8; 2002. DOI: https://doi.org/10.1111/j.1349-7006.2002.tb01206.x

SILVA, S.L.; SILVA, S.F. R; FARIAS I.N; MOTA, R.S;; MORAES, M.E; CAMPOS, H.H; FERREIRA, F.V; FILHO, M.O.M. A new model of isolation of Walker's tumor using the gradient of Ficoll-Hypaque.Acta Cirurgica Brasileira.; v. 21, n.2, p.101-105; 2006. DOI: https://doi.org/10.1590/S0102-86502006000200009

SIEGEL, R.L.; MILER, K.D.; JEMAL, A. Cancer Statistics, CA: a Cancer Journal for Clinicians; v.65; n.1; p. 5-29; 2015. DOI: https://doi.org/10.3322/caac.21254

TEIXEIRA, L. A.; FONSECA, C. O. From Unknown illness to public health problem: INCA and cancer control in Brazil [Internet]. Rio de Janeiro: Ministry of Health; 2007 172p p. ISBN: 978-85-334-1446-4.

Available from: http:// bvsms.saude.gov.br/bvs/publicacoes/doenca_desconhecida_saude_publica.pdf

VADALÀ, M; MORALES-MEDINA, J.C; VALLELUNGA, A; PALMIERI, B; LAURINO, C; LANNITTI, T. Cancer Medicine, v.5, n. 11, p. 3128-3139, 2016. DOI: https://doi.org/10.1002/cam4.861

WHO - World Health Organization, 2006. What are electromagnetic fields? Available in http://www.who. Int/peh-emf/about/WHATISEMF/en/ [accessed June 9, 2008]

YUAN, L-Q; WANG, C; ZHU, K; LI H-M; GU, W-Z; ZHOU, D-M; LAI, J-Q; ZHOU, D; LV Y; TOFANI, S; CHEN, X. The antitumor effect the staticandextremelylowfrequencymagneticfiedsagainstnephroblastomaandneuro blastoma. Bioelectromagnetics, v. 39, n. 5, p. 375-385, 2018. DOI: https://doi.org/10.1002/bem.22124

ZABLOTSKII, V; POLYAKOVA, T; LUNOV, O; DEJNEKA, A. How a High-Gradient Magnetic Field Could Affect Cell Life. Sci Re p; v.6; p.37407; 2016. DOI: https://doi.org/10.1038/srep37407

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2022-07-01

How to Cite

Jabrayan, T. da C. P., Tosta Ramalho, R., Nascimento, V. A., da Cruz Penha Friozi, M. ., Borges de Menezes Neto, J. ., Gonçalves Soares dos Santos, P. ., Domingos de Souza, I. ., Vieira Ramos, H. ., & Barbosa Ramos, I. B. R. (2022). Action of cyanogenic substances and magnetic field in the reduction of neoplasms: An integrative literature review. International Journal for Innovation Education and Research, 10(7), 18-38. https://doi.org/10.31686/ijier.vol10.iss7.3738
Received 2022-03-28
Accepted 2022-04-20
Published 2022-07-01

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