Regioselective Nitration of Halogenated Benzo[c]cinnolines and Benzenoids
DOI:
https://doi.org/10.31686/ijier.vol3.iss8.419Abstract
Electrophilic nitration of halo-substituted benzo[c]cinnolines and benzenoids has been achieved regioselectively. The nitro group entry was always ortho to the halo group or/and the aromatic ring. This regioselective electrophilic ortho-nitration was accomplished in mixed acid/mild temperature conditions. Regioselectivity ortho to the halo/ring group(s) was observed with or without proximal steric hindrance. Chlorides and bromides worked equally well in directing these high-yielding ortho-selective reactions.
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Copyright (c) 2015 Ayunna K. Epps, Tonya M. Horne, ShaNese Jackson, Bridgette Sands, and Ghislain Mandouma
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