Antioxidant effect of Physalis angulata fruit on cells exposed to 2,4- dichlorophenoxyacetic acid

• Roberta Cattaneo Horn

  University of Cruz Alta, Brazil

  Author

• GABRIELA TASSOTTI GELATTI

  University of Cruz Alta, Brazil

  Author

• JANA KOEFENDER

  University of Cruz Alta, Brazil

  Author

• DIEGO PASCOAL GOLLE

  University of Cruz Alta, Brazil

  Author

• MARIANA SPANEMBERG MAYER

  University of Cruz Alta, Brazil

  Author

• TIAGO ANTONIO HERINGER

  University of Cruz Alta, Brazil

  Author

• MAURICIO BATISTELLA PASINI

  University of Cruz Alta, Brazil

  Author

• ANA CAROLINE TISSIANI

  University of Cruz Alta, Brazil

  Author

• AIME CUNHA ARRUDA

  University of Cruz Alta, Brazil

  Author

• LAURA RUBIN

  University of Cruz Alta, Brazil

  Author

• RAFAELA DA ROSA RECKTENWALD

  University of Cruz Alta, Brazil

  Author

• PAULO RICARDO MOREIRA

  University of Cruz Alta, Brazil

  Author

• CAROLINE ALEGRANSI

  University of Cruz Alta, Brazil

  Author

Several in vitro studies have described the erythrocyte toxicity mechanism response to the 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolites, strongly related to oxidative stress. Compounds such as ascorbic acid and flavonoids, present in various fructiferous plants like Physalis angulata L.- Solanaceae, are exogenous sources of antioxidants, which have aroused interest because of its beneficial biological effects to health by capturing oxygen reactive species. Here, was investigated the cytotoxic effects of the 2,4-D in human erythrocytes exposed to this herbicide and treated with the juice of P. angulata fruits. Analyzing the oxidant and antioxidant mechanisms in these cells in vitro, was demonstrated that the damage mechanism by the Physalis juice occurred at the level of cellular proteins and membranes, altering levels of endogenous antioxidants components such as reduced glutathione and uric acid, and exogenous like vitamin C. Our results indicate new insights into the mechanism of human erythrocytes response exposed to the P. angulata juice, providing wayforward to future studies of cytotoxicity.

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Copyright (c) 2019 Roberta Cattaneo Horn, Gabriela Tassotti Gelatti, Jana Koefender, Diego Pascoal Golle, Mariana Spanemberg Mayer, Tiago Antonio Heringer, Mauricio Batistella Pasini, Ana Caroline Tissiani, Aime Cunha Arruda, Laura Rubin, Rafaela Da Rosa Recktenwald, Paulo Ricardo Moreira, Caroline Alegransi

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